Difference between revisions of "Keratoacanthoma"
Jump to navigation
Jump to search
(+cat.) |
(split-out into separate article) |
||
| Line 1: | Line 1: | ||
'''Keratoacanthoma''' is clinically worrisome lesion that classically arise on the nose. | |||
It is abbreviated '''KA'''. | |||
==General== | |||
*Generally considered to be benign. | |||
**Rare reports of [[metastases]] suggesting it may be a form of [[squamous cell carcinoma]].<ref>{{cite journal |author=Mandrell JC, Santa Cruz D |title=Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? |journal=Semin Diagn Pathol |volume=26 |issue=3 |pages=150–63 |year=2009 |month=August |pmid=20043514 |doi= |url=}}</ref> | |||
===Clinical=== | |||
*May grow rapidly (weeks or months) then involute. | |||
*Main DDx is [[squamous cell carcinoma]]. | |||
*Exophytic lesion, well-circumscribed. | |||
==Microscopic== | |||
Features:<ref name=Ref_Klatt378>{{Ref Klatt|378}}</ref> | |||
*Expansion of stratum spinosum - pushing [[tongue]]-like downward growth of epidermis into the dermis. | |||
*Keratin collection ("keratin plug") at the center of lesion-superficial aspect. | |||
*Cells have glassy pink cytoplasm. | |||
*Minimal/no nuclear atypia. | |||
Note: | |||
*Classically described as a "volcano lesion" with pale pink cells. | |||
*May have features of regression - [[PMN]]s, fibrosis (???). | |||
DDx:<ref name=Ref_Derm379>{{Ref Derm|379}}</ref> | |||
*[[Verruca vulgaris]]. | |||
*Conventional [[squamous cell carcinoma of the skin]] with a cup-shape. | |||
*[[Pseudoepitheliomatous hyperplasia]]. | |||
===Image=== | |||
<gallery> | |||
Image:Skin_keratoacanthoma_whole_slide.jpg | Keratoacanthoma. (WC) | |||
</gallery> | |||
==See also== | |||
*[[Dermatologic neoplasms]]. | |||
*[[Dermatopathology]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 11:40, 4 July 2013
Keratoacanthoma is clinically worrisome lesion that classically arise on the nose. It is abbreviated KA.
General
- Generally considered to be benign.
- Rare reports of metastases suggesting it may be a form of squamous cell carcinoma.[1]
Clinical
- May grow rapidly (weeks or months) then involute.
- Main DDx is squamous cell carcinoma.
- Exophytic lesion, well-circumscribed.
Microscopic
Features:[2]
- Expansion of stratum spinosum - pushing tongue-like downward growth of epidermis into the dermis.
- Keratin collection ("keratin plug") at the center of lesion-superficial aspect.
- Cells have glassy pink cytoplasm.
- Minimal/no nuclear atypia.
Note:
- Classically described as a "volcano lesion" with pale pink cells.
- May have features of regression - PMNs, fibrosis (???).
DDx:[3]
- Verruca vulgaris.
- Conventional squamous cell carcinoma of the skin with a cup-shape.
- Pseudoepitheliomatous hyperplasia.
Image
Keratoacanthoma. (WC)
See also
References
- ↑ Mandrell JC, Santa Cruz D (August 2009). "Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma?". Semin Diagn Pathol 26 (3): 150–63. PMID 20043514.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 378. ISBN 978-1416002741.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 379. ISBN 978-0443066542.