Difference between revisions of "Juvenile granulosa cell tumour"
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'''Juvenile granulosa cell tumour''' is an uncommon [[ovarian tumour]] in the ''sex cord stromal tumours'' group. | |||
==General== | |||
*May secrete estrogen. | |||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | |||
**May present as precocious puberty.<ref name=pmid21526089>{{Cite journal | last1 = Hashemipour | first1 = M. | last2 = Moaddab | first2 = MH. | last3 = Nazem | first3 = M. | last4 = Mahzouni | first4 = P. | last5 = Salek | first5 = M. | title = Granulosa cell tumor in a six-year-old girl presented as precocious puberty. | journal = J Res Med Sci | volume = 15 | issue = 4 | pages = 240-2 | month = Jul | year = 2010 | doi = | PMID = 21526089 }}</ref> | |||
*Reported in males.<ref>URL: [http://path.upmc.edu/cases/case631.html http://path.upmc.edu/cases/case631.html]. Accessed on: 26 January 2012.</ref> | |||
==Gross== | |||
*Classically solid. | |||
==Microscopic== | |||
Features: | |||
*Microcystic spaces. | |||
*Moderate-to-marked nuclear atypia. | |||
*Cuboidal-to-polygonal cell in sheets or stands or cords. | |||
*Basophilic cytoplasm. | |||
Notes: | |||
*Juvenile variant of GCT has more nuclear pleomorphism. | |||
===Images=== | |||
<gallery> | |||
Image:Juvenile_granulosa_cell_tumour_-_intermed_mag.jpg | Juvenile granulosa cell tumour - intermed. mag. (WC) | |||
Image:Juvenile_granulosa_cell_tumour_-_high_mag.jpg | Juvenile granulosa cell tumour - high mag. (WC) | |||
Image:Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg | Juvenile granulosa cell tumour - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
* Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref> | |||
** Inhibin negative in ''[[Brenner tumour]]''. | |||
*Calretinin +ve. | |||
==Molecular== | |||
:''Currently '''not''' used for the diagnosis.'' | |||
*Trisomy 12.<ref name=pmid1466394>{{Cite journal | last1 = Schofield | first1 = DE. | last2 = Fletcher | first2 = JA. | title = Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material. | journal = Am J Pathol | volume = 141 | issue = 6 | pages = 1265-9 | month = Dec | year = 1992 | doi = | PMID = 1466394 }}</ref><ref name=pmid12218213>{{Cite journal | last1 = Mayr | first1 = D. | last2 = Kaltz-Wittmer | first2 = C. | last3 = Arbogast | first3 = S. | last4 = Amann | first4 = G. | last5 = Aust | first5 = DE. | last6 = Diebold | first6 = J. | title = Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. | journal = Mod Pathol | volume = 15 | issue = 9 | pages = 951-7 | month = Sep | year = 2002 | doi = 10.1097/01.MP.0000024290.55261.14 | PMID = 12218213 }} | |||
</ref> | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Ovarian tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 03:49, 18 February 2014
Juvenile granulosa cell tumour is an uncommon ovarian tumour in the sex cord stromal tumours group.
General
- May secrete estrogen.
- May present with endometrial pathology, e.g. endometrial hyperplasia or endometrioid endometrial carcinoma.
- May present as precocious puberty.[1]
- Reported in males.[2]
Gross
- Classically solid.
Microscopic
Features:
- Microcystic spaces.
- Moderate-to-marked nuclear atypia.
- Cuboidal-to-polygonal cell in sheets or stands or cords.
- Basophilic cytoplasm.
Notes:
- Juvenile variant of GCT has more nuclear pleomorphism.
Images
Juvenile granulosa cell tumour - intermed. mag. (WC)
Juvenile granulosa cell tumour - high mag. (WC)
Juvenile granulosa cell tumour - very high mag. (WC)
IHC
- Inhibin positive.[3]
- Inhibin negative in Brenner tumour.
- Calretinin +ve.
Molecular
- Currently not used for the diagnosis.
See also
References
- ↑ Hashemipour, M.; Moaddab, MH.; Nazem, M.; Mahzouni, P.; Salek, M. (Jul 2010). "Granulosa cell tumor in a six-year-old girl presented as precocious puberty.". J Res Med Sci 15 (4): 240-2. PMID 21526089.
- ↑ URL: http://path.upmc.edu/cases/case631.html. Accessed on: 26 January 2012.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1102. ISBN 0-7216-0187-1.
- ↑ Schofield, DE.; Fletcher, JA. (Dec 1992). "Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.". Am J Pathol 141 (6): 1265-9. PMID 1466394.
- ↑ Mayr, D.; Kaltz-Wittmer, C.; Arbogast, S.; Amann, G.; Aust, DE.; Diebold, J. (Sep 2002). "Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors.". Mod Pathol 15 (9): 951-7. doi:10.1097/01.MP.0000024290.55261.14. PMID 12218213.