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Difference between revisions of "Dermatopathology"
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Pathology is a significant part of dermatology and dermatologists spend five years in residency. So, it is a huge area. | Pathology is a significant part of dermatology and dermatologists spend five years in residency. So, it is a huge area. | ||
=Layers of the skin= | =Histology= | ||
==Layers of the skin== | |||
*Epidermis - outer most layer, avascular, separated from dermis by a basement membrane, epithelial tissue. | *Epidermis - outer most layer, avascular, separated from dermis by a basement membrane, epithelial tissue. | ||
*Dermis - below the epidermis, vascular, separated from the epidermis by a basement membrane, connective tissue. | *Dermis - below the epidermis, vascular, separated from the epidermis by a basement membrane, connective tissue. | ||
*Subdermis - below the dermis, connective tissue. | *Subdermis - below the dermis, connective tissue. | ||
== | ==Epidermis== | ||
Epidermis layers - from the surface to epidermal-dermal junction: | Epidermis layers - from the surface to epidermal-dermal junction: | ||
*Stratum corneum. | *Stratum corneum. | ||
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Mnemonic: ''Corn Lovers Grow Several Bales''. | Mnemonic: ''Corn Lovers Grow Several Bales''. | ||
=Adnexal structures= | ===Cells of the epidermis=== | ||
*Keratinocytes. | |||
**Usu. eosinophilic cytoplasm - '''important feature'''. | |||
**May have clear perinuclear halo (glycogenated keratinocytes). | |||
**Intercellular bridges (high power) - '''key feature'''. | |||
*Melanocytes. | |||
**Usu. basal location. | |||
**Epithelioid or dentritic morphology. | |||
**Pericellular clearing - '''key feature'''. | |||
**Clear cytoplasm. | |||
**+/-Pigmentation. | |||
*Other: | |||
**Toker cell. | |||
**Neutrophils. | |||
***Trilobated nuclei - 2-3 little dots - '''key feature'''. | |||
**Lymphocytes. | |||
***Small (round) nucleus. | |||
***Scant/indistinct cytoplasm. | |||
**Other foreign cells: | |||
***[[Paget disease]]: large cells with clear cytoplasm, may cluster, above basal layer. | |||
==Adnexal structures== | |||
The top five structures of the skin:<ref>{{Ref Derm|4-8}}</ref> | The top five structures of the skin:<ref>{{Ref Derm|4-8}}</ref> | ||
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