Difference between revisions of "Extramammary Paget disease"
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*Benign Toker cell hyperplasia. | *Benign Toker cell hyperplasia. | ||
*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
*Bowen disease | *[[Bowen disease]]. | ||
*[[Eccrine carcinoma]]. | *[[Eccrine carcinoma]]. | ||
==IHC== | |||
Panel: | |||
*CEA +ve (-ve in Bowen's disease, -ve in Toker cells). | |||
*CK7 +ve. (???) | |||
**Toker cells CK7 +ve.<ref name=pmid19601945>{{Cite journal | last1 = Nofech-Mozes | first1 = S. | last2 = Hanna | first2 = W. | title = Toker cells revisited. | journal = Breast J | volume = 15 | issue = 4 | pages = 394-8 | month = | year = | doi = 10.1111/j.1524-4741.2009.00743.x | PMID = 19601945 }}</ref> | |||
*S100 -ve, HMB-45 -ve (both typically +ve in melanoma). | |||
Additional: | |||
*HER2/neu - usually +ve. | |||
*CK5/6 -ve.<ref>RS. May 2010.</ref> | |||
**Usu. +ve in [[squamous cell carcinoma]]. | |||
==See also== | ==See also== | ||
Revision as of 14:12, 2 September 2011
Extramammary Paget disease, abbreviated EMPD, is a skin disease. As the name suggests, there is also a Paget disease of the breast.
There is also a Paget disease of the bone - just to make things confusing. This is dealt with in the bone article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article
General
- Usually not associated with malignancy, unlike the Paget disease of the breast - important difference.
- Classically seen in the vulva.
- May afflict penis.[1]
Microscopic
Features:
- Epitheliod morphology (round/ovoid).
- Cells nested or single.
- Clear/pale cytoplasm key feature - may also be eosinophilic.
- Large nucleoli.
Images:
DDx
- Benign Toker cell hyperplasia.
- Malignant melanoma.
- Bowen disease.
- Eccrine carcinoma.
IHC
Panel:
- CEA +ve (-ve in Bowen's disease, -ve in Toker cells).
- CK7 +ve. (???)
- Toker cells CK7 +ve.[2]
- S100 -ve, HMB-45 -ve (both typically +ve in melanoma).
Additional:
- HER2/neu - usually +ve.
- CK5/6 -ve.[3]
- Usu. +ve in squamous cell carcinoma.
See also
References
- ↑ Ekwueme, KC.; Zakhour, HD.; Parr, NJ. (2009). "Extramammary Paget's disease of the penis: a case report and review of the literature.". J Med Case Reports 3: 4. doi:10.1186/1752-1947-3-4. PMID 19126202.
- ↑ Nofech-Mozes, S.; Hanna, W.. "Toker cells revisited.". Breast J 15 (4): 394-8. doi:10.1111/j.1524-4741.2009.00743.x. PMID 19601945.
- ↑ RS. May 2010.