Difference between revisions of "Fumarate hydratase-deficient renal cell carcinoma"

Fumarate hydratase-deficient renal cell carcinoma (view source)

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 *Often aggressive - significant cause of mortality.<ref name=pmid24441663>{{Cite journal  | last1 = Chen | first1 = YB. | last2 = Brannon | first2 = AR. | last3 = Toubaji | first3 = A. | last4 = Dudas | first4 = ME. | last5 = Won | first5 = HH. | last6 = Al-Ahmadie | first6 = HA. | last7 = Fine | first7 = SW. | last8 = Gopalan | first8 = A. | last9 = Frizzell | first9 = N. | title = Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry. | journal = Am J Surg Pathol | volume = 38 | issue = 5 | pages = 627-37 | month = May | year = 2014 | doi = 10.1097/PAS.0000000000000163 | PMID = 24441663 }}</ref>
 *See ''[[hereditary leiomyomatosis and renal cell carcinoma syndrome]]''.
-*Small tumours may metastasize.
+*Small tumours in the context of HLRCC may metastasize.<ref name=pmid17509289>{{cite journal |authors=Grubb RL, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, Torres-Cabala C, Glenn GM, Choyke P, Merino MJ, Zbar B, Pinto PA, Srinivasan R, Coleman JA, Linehan WM |title=Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer |journal=J Urol |volume=177 |issue=6 |pages=2074–9; discussion 2079–80 |date=June 2007 |pmid=17509289 |doi=10.1016/j.juro.2007.01.155 |url=}}</ref>
 ==Microscopic==