Difference between revisions of "Eosinophilic vacuolated tumour"
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| Line 7: | Line 7: | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 16: | Line 16: | ||
| Grossing = | | Grossing = | ||
| Staging = | | Staging = | ||
| Site = | | Site = [[kidney]] - see ''[[kidney tumours]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = [[tuberous sclerosis]] | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = very rare? (evolving entity) | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = unknown (evolving entity) | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = other [[renal tumours]] | ||
| Tx = | | Tx = excision | ||
}} | }} | ||
'''High-grade oncocytic renal tumour''', abbreviated '''HOT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book. | '''High-grade oncocytic renal tumour''', abbreviated '''HOT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book. | ||
Revision as of 21:55, 14 July 2019
| Eosinophilic vacuolated tumour | |
|---|---|
| Diagnosis in short | |
 Micrograph of a high-grade oncocytic tumour of the kidney. H&E stain. | |
| LM DDx | renal oncocytoma, renal hybrid oncocytic/chromophobe tumour, chromophobe renal cell carcinoma, other renal tumours with eosinophilic cytoplasm |
| IHC | PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | tuberous sclerosis |
|
| |
| Prevalence | very rare? (evolving entity) |
| Prognosis | unknown (evolving entity) |
| Clin. DDx | other renal tumours |
| Treatment | excision |
High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.
General
- Previously lumped into renal hybrid oncocytic/chromophobe tumour.
- Evolving entity.
- May be seen within the context of tuberous sclerosis.[1]
Microscopic
Features:[2]
- Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
- Round nuclei
- No "raisinoid" nuclei typical of chromophobe RCC.
- Prominent nucleoli (ISUP nucleolar grade 3).
- No perinuclear halos.
DDx:
- Renal oncocytoma.
- Renal hybrid oncocytic/chromophobe tumour.
- Chromophobe renal cell carcinoma.
- Other renal tumours with eosinophilic cytoplasm.
Images
HOT - low mag. (WC)
HOT - intermed. mag. (WC)
HOT - intermed. mag. (WC)
HOT - high mag. (WC)
HOT - high mag. (WC)
HOT - very high mag. (WC)
IHC
Features:[2]
- PAX8 +ve (13 of 13 cases).
- AE1/AE3 +ve.
- CK18 +ve.
- SDHB +ve.
- CD10 +ve (12 of 13 cases).
- HMB45 -ve.
- Melan A -ve.
- TFE3 -ve.
See also
References
- ↑ Trpkov, K.; Bonert, M.; Gao, Y.; Kapoor, A.; He, H.; Yilmaz, A.; Gill, AJ.; Williamson, SR. et al. (Apr 2019). "High-grade oncocytic tumour (HOT) of kidney in a patient with tuberous sclerosis complex.". Histopathology. doi:10.1111/his.13876. PMID 31002177.
- ↑ 2.0 2.1 He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.