Difference between revisions of "Parathyroid carcinoma"
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| Line 18: | Line 18: | ||
| Site = [[parathyroid gland]] | | Site = [[parathyroid gland]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = familial primary hyperparathyroidism | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
Revision as of 04:08, 11 June 2019
| Parathyroid carcinoma | |
|---|---|
| Diagnosis in short | |
 Parathyroid carcinoma. H&E stain. | |
| IHC | PAX8 +ve, Ki-67 >6% +ve |
| Site | parathyroid gland |
|
| |
| Syndromes | familial primary hyperparathyroidism |
|
| |
| Prevalence | very rare |
| Prognosis | poor |
| Clin. DDx | parathyroid adenoma, parathyroid hyperplasia, thyroid cancer |
| Treatment | surgical excision |
Parathyroid carcinoma is a rare epithelial malignancy of the parathyroid gland.
General
- Extremely rare.
- May be seen in the context of familial primary hyperparathyroidism (PHPT).[1]
Microscopic
Features:[2]
- Histologically normal parathyroid cells.
- Cytologic features not reliable for diagnosis.
- Fibrous capsule.
- Invasion of surrounding tissue - key feature.
- +/-Metastasis - diagnostic feature.
Note:
- Diagnosis of parathyroid carcinoma is like that of malignant pheochromocytoma - cytology useless, tissue invasion and metastases are the key features.
Images
PC - low mag. (WC)
PC - intermed. mag. (WC)
PC - intermed. mag. (WC)
PC - high mag. (WC)
PC - very high mag. (WC)
PC - low mag. (WC)
PC - intermed. mag. (WC)
PC - very low mag. (WC)
PC - low mag. (WC)
PC - intermed. mag. (WC)
PC - high mag. (WC)
IHC
- Ki-67 >6% of cells positive - supports diagnosis.[3]
- Parathyroid adenomas and hyperplasias ~ 3%.
- PAX8 +ve.[4]
See also
References
- ↑ Cetani, F.; Pardi, E.; Marcocci, C. (Jun 2018). "Parathyroid carcinoma: a clinical and genetic perspective.". Minerva Endocrinol 43 (2): 144-155. doi:10.23736/S0391-1977.17.02737-7. PMID 28949121.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1128. ISBN 978-1416031215.
- ↑ Abbona, GC.; Papotti, M.; Gasparri, G.; Bussolati, G. (Feb 1995). "Proliferative activity in parathyroid tumors as detected by Ki-67 immunostaining.". Hum Pathol 26 (2): 135-8. PMID 7860042.
- ↑ Ordóñez, NG. (May 2012). "Value of PAX 8 immunostaining in tumor diagnosis: a review and update.". Adv Anat Pathol 19 (3): 140-51. doi:10.1097/PAP.0b013e318253465d. PMID 22498579.