Difference between revisions of "ALK translocation renal cell carcinoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Mix of morphologies - rhabdoid, sarcomatoid, "[[unclassified renal cell carcinoma]]". | *Mix of morphologies - rhabdoid, sarcomatoid, "[[unclassified renal cell carcinoma]]", [[papillary renal cell carcinoma]]. | ||
DDx: | DDx: | ||
*[[Unclassified renal cell carcinoma]] | *[[Unclassified renal cell carcinoma]] | ||
*[[Renal medullary carcinoma]]. | *[[Renal medullary carcinoma]]. | ||
*[[Papillary renal cell carcinoma]].<ref namd=pmid29685646>{{Cite journal | last1 = Pal | first1 = SK. | last2 = Bergerot | first2 = P. | last3 = Dizman | first3 = N. | last4 = Bergerot | first4 = C. | last5 = Adashek | first5 = J. | last6 = Madison | first6 = R. | last7 = Chung | first7 = JH. | last8 = Ali | first8 = SM. | last9 = Jones | first9 = JO. | title = Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma. | journal = Eur Urol | volume = 74 | issue = 1 | pages = 124-128 | month = 07 | year = 2018 | doi = 10.1016/j.eururo.2018.03.032 | PMID = 29685646 }}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 17:50, 17 March 2019
ALK translocation renal cell carcinoma is a proposed entity within the Vancouver modification of the 2004 WHO classification of renal neoplasia.[1]
General
- Extremely rare.
- May be related to renal medullary carcinoma which is reported to have an ALK rearrangement - t(2;10)(p23;q22).[2]
Microscopic
Features:
- Mix of morphologies - rhabdoid, sarcomatoid, "unclassified renal cell carcinoma", papillary renal cell carcinoma.
DDx:
- Unclassified renal cell carcinoma
- Renal medullary carcinoma.
- Papillary renal cell carcinoma.Cite error: Invalid
<ref>tag; invalid names, e.g. too many
IHC
- ALK +ve.
- SMARCB1 -ve.
See also
References
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
- ↑ Mariño-Enríquez, A.; Ou, WB.; Weldon, CB.; Fletcher, JA.; Pérez-Atayde, AR. (Mar 2011). "ALK rearrangement in sickle cell trait-associated renal medullary carcinoma.". Genes Chromosomes Cancer 50 (3): 146-53. doi:10.1002/gcc.20839. PMID 21213368.