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Difference between revisions of "Littoral cell angioma"
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m
haemangioendothelioma variant
m (CD21+) |
m (haemangioendothelioma variant) |
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| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = solitary hypodense lesion | | Rads = solitary hypodense lesion | ||
| Endoscopy = | | Endoscopy = | ||
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| Tx = | | Tx = | ||
}} | }} | ||
'''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon | '''Littoral cell angioma''', abbreviated '''LCA''', is an uncommon [[vascular lesions|vascular lesion]] of the [[spleen]]. Regarded as benign, rare cases have shown malignant behaviour and have been labelled as [[littoral cell hemangioendothelioma]].<ref>{{Cite journal | last1 = Ben-Izhak | first1 = O. | last2 = Bejar | first2 = J. | last3 = Ben-Eliezer | first3 = S. | last4 = Vlodavsky | first4 = E. | title = Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour. | journal = Histopathology | volume = 39 | issue = 5 | pages = 469-75 | month = Nov | year = 2001 | doi = | PMID = 11737304 }}</ref><ref name=pmid24420309>{{Cite journal | last1 = He | first1 = P. | last2 = Yan | first2 = XD. | last3 = Wang | first3 = JR. | last4 = Guo | first4 = RC. | last5 = Zhang | first5 = HB. | title = Splenic littoral cell hemangioendothelioma: report of a case with hepatic metastases and review of the literature. | journal = J Clin Ultrasound | volume = 42 | issue = 5 | pages = 308-12 | month = Jun | year = 2014 | doi = 10.1002/jcu.22120 | PMID = 24420309 }}</ref> | ||
''Angioma'', in general, is dealt with in ''[[vascular malformations]]''. | ''Angioma'', in general, is dealt with in ''[[vascular malformations]]''. | ||
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Features:<ref name=pmid15329769>{{Cite journal | last1 = Tan | first1 = YM. | last2 = Chuah | first2 = KL. | last3 = Wong | first3 = WK. | title = Littoral cell angioma of the spleen. | journal = Ann Acad Med Singapore | volume = 33 | issue = 4 | pages = 524-6 | month = Jul | year = 2004 | doi = | PMID = 15329769 | url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref> | Features:<ref name=pmid15329769>{{Cite journal | last1 = Tan | first1 = YM. | last2 = Chuah | first2 = KL. | last3 = Wong | first3 = WK. | title = Littoral cell angioma of the spleen. | journal = Ann Acad Med Singapore | volume = 33 | issue = 4 | pages = 524-6 | month = Jul | year = 2004 | doi = | PMID = 15329769 | url=http://www.annals.edu.sg/pdf200408/V33N4p524.pdf }}</ref> | ||
*Rare. | *Rare. | ||
*Benign | *Benign (except for rare cases - see above) | ||
Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal | last1 = Dascalescu | first1 = CM. | last2 = Wendum | first2 = D. | last3 = Gorin | first3 = NC. | title = Littoral-cell angioma as a cause of splenomegaly. | journal = N Engl J Med | volume = 345 | issue = 10 | pages = 772-3 | month = Sep | year = 2001 | doi = 10.1056/NEJM200109063451016 | PMID = 11547761 | url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref> | Clinical:<ref name=pmid15329769/><ref name=pmid11547761>{{Cite journal | last1 = Dascalescu | first1 = CM. | last2 = Wendum | first2 = D. | last3 = Gorin | first3 = NC. | title = Littoral-cell angioma as a cause of splenomegaly. | journal = N Engl J Med | volume = 345 | issue = 10 | pages = 772-3 | month = Sep | year = 2001 | doi = 10.1056/NEJM200109063451016 | PMID = 11547761 | url=http://www.nejm.org/doi/full/10.1056/NEJM200109063451016 }}</ref> | ||
*Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging. | *Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging. | ||
*Regarded as benign | |||
*Case series show strong association with synchronous malignancy.<ref name=pmid24987971>{{Cite journal | last1 = Sarandria | first1 = JJ. | last2 = Escano | first2 = M. | last3 = Kamangar | first3 = F. | last4 = Farooqui | first4 = S. | last5 = Montgomery | first5 = E. | last6 = Cunningham | first6 = SC. | title = Massive splenomegaly correlates with malignancy: 180 cases of splenic littoral cell tumors in the world literature. | journal = Minerva Chir | volume = 69 | issue = 4 | pages = 229-37 | month = Aug | year = 2014 | doi = | PMID = 24987971 }}</ref> | |||
Note: | Note: | ||