Difference between revisions of "P53"
Jump to navigation
Jump to search
| Line 11: | Line 11: | ||
| Subspecial = | | Subspecial = | ||
| Pattern = | | Pattern = | ||
| Positive = nuclear staining | | Positive = nuclear staining | ||
| Negative = | | Negative = | ||
| Other = | | Other = | ||
}} | }} | ||
'''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]]. | '''p53''' is a [[tumour suppressor]] commonly implicated in cancer and common [[immunostain]]. | ||
==Interpretation== | |||
*p53 may be one of the most misinterpreted stains. | |||
**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal | last1 = Yemelyanova | first1 = A. | last2 = Vang | first2 = R. | last3 = Kshirsagar | first3 = M. | last4 = Lu | first4 = D. | last5 = Marks | first5 = MA. | last6 = Shih | first6 = IeM. | last7 = Kurman | first7 = RJ. | title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1248-53 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.85 | PMID = 21552211 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 15:27, 19 March 2018
| P53 | |
|---|---|
| Immunostain in short | |
 p53 staining in an anaplastic astrocytoma. | |
| Use | cancer versus benign, prognostication |
| Positive | nuclear staining |
p53 is a tumour suppressor commonly implicated in cancer and common immunostain.
Interpretation
- p53 may be one of the most misinterpreted stains.
- TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).[1]
See also
References
- ↑ Yemelyanova, A.; Vang, R.; Kshirsagar, M.; Lu, D.; Marks, MA.; Shih, IeM.; Kurman, RJ. (Sep 2011). "Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis.". Mod Pathol 24 (9): 1248-53. doi:10.1038/modpathol.2011.85. PMID 21552211.