Talk:Non-malignant skin disease

Urticaria

Microscopic description

The sections show a mild, superficial dermal perivascular lymphoeosinophilic infiltration. Rare eosinophils are seen in the dermis distant from blood vessels. The epidermis shows normal maturation and is not inflamed. No dysplastic changes are present.

Final diagnosis

A. Skin, posterior left thigh, biopsy - dermal perivascular lymphoeosinophilic infiltration, see comment.

Comment

The sections show a mild, superficial dermal perivascular lymphoeosinophilic infiltration. Rare eosinophils are seen in the dermis distant from blood vessels. The epidermis shows normal maturation and is not inflammed.

Pilomatrixoma

Microscopic description

The sections show a fibrous encapsulated lesion with nests of benign basaloid squamous cells, occasional squamous pearls, multi-nucleated foreign body-type giant cells, and abundant anucleated squamous cells ("ghost cells"). Focal, punctate calcifications are present. Small collections of lymphocytes are present. There is no evidence of dysplasia.

Final diagnosis

Neck mass, left, excision - Pilomatrixoma

Dermatofibroma

Microscopic description

Sections show a well-circumscribed deep dermal, cellular lesion with thick bundles of collagen through-out. The predominant cell type has regular, pale vesicular nuclei without prominent nucleoli and moderate pale cytoplasm. No mitotic activity is present. Histocytes and lymphocytes are present focally. The lesion is incompletely excised. The overlying epidermis and superficial dermis have no pathology.

Final diagnosis

Soft tissue, right anterior calf, excision: - Cellular dermatofibroma.