Difference between revisions of "Multiple endocrine neoplasia"

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Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>
Characteristics:<ref name=Ref_PBoD8_1162>{{Ref PBoD8|1162}}}}</ref>
*Medullary [[thyroid]] carcinoma - in almost 100%.
*Medullary [[thyroid]] carcinoma - in almost 100%.
*Ganglioneuromatosis of the alimentary tract.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/162300 http://www.ncbi.nlm.nih.gov/omim/162300]. Accessed on: 19 November 2010.</ref><ref name=pmid17306015>{{cite journal |author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' |title=Multiple rectal carcinoids with diffuse ganglioneuromatosis |journal=World J Surg Oncol |volume=5 |issue= |pages=19 |year=2007 |pmid=17306015 |pmc=1805501 |doi=10.1186/1477-7819-5-19 |url=}}</ref>
**Extra large nerves in GI tract.


Images:  
Images:  
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Characteristics:
Characteristics:
*[[Marfan syndrome|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8|1160}}}}</ref>
*[[Marfan syndrome|Marfanoid]] habitus.<ref name=Ref_PBoD8_1160>{{Ref PBoD8|1160}}}}</ref>
*[[Neuroma]]s.
*Ganglioneuromatosis of the alimentary tract.<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/162300 http://www.ncbi.nlm.nih.gov/omim/162300]. Accessed on: 19 November 2010.</ref><ref name=pmid17306015>{{cite journal |author=Haraguchi M, Kinoshita H, Koori M, ''et al.'' |title=Multiple rectal carcinoids with diffuse ganglioneuromatosis |journal=World J Surg Oncol |volume=5 |issue= |pages=19 |year=2007 |pmid=17306015 |pmc=1805501 |doi=10.1186/1477-7819-5-19 |url=}}</ref>
**Extra large nerves in GI tract.


==References==
==References==

Revision as of 21:16, 19 March 2011

Multiple endocrine neoplasia, abbreviated MEN, refers to collection of different genetic abnormalities that lead to endocrine neoplasms.

Simple

MEN 1

Memory device: 3 Ps.

MEN 2A/2B (II/III)

Notes:

  • BOTH have parathyroid adenoma.
  • EACH has one below and one above the diaphragm.

Details

MEN 1

Characteristics:[2]

  • Endocrine tumours usu. lead to most of the morbidity.
    • Usu. arise in the duodenum.
      • Zollinger-Ellison syndrome is common.

MEN 2A

Characteristics:[2]

  • Medullary thyroid carcinoma - in almost 100%.

Images:

Trivia:

MEN 2B

Characteristics:

References

  1. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 2 September 2010.
  2. 2.0 2.1 2.2 2.3 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1162. ISBN 978-1416031215. }}
  3. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1160. ISBN 978-1416031215. }}
  4. URL: http://www.ncbi.nlm.nih.gov/omim/162300. Accessed on: 19 November 2010.
  5. Haraguchi M, Kinoshita H, Koori M, et al. (2007). "Multiple rectal carcinoids with diffuse ganglioneuromatosis". World J Surg Oncol 5: 19. doi:10.1186/1477-7819-5-19. PMC 1805501. PMID 17306015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805501/.