Difference between revisions of "Molecular pathology"
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'''Molecular pathology''' is the future of pathology. | '''Molecular pathology''' is the future of pathology. | ||
==Overview== | |||
Molecular pathology can be divided as follows: | |||
<center> | |||
{{familytree/start}} | |||
{{familytree | | | |A11| | | | |A11 =Molecular<br>pathology}} | |||
{{familytree | |,|-|-|^|-|-|.|}} | |||
{{familytree | B11 | | | | B12 |B11=Molecular|B12=Cytogenetics}} | |||
{{familytree/end}} | |||
</center> | |||
===Molecular=== | |||
General: | |||
*Very small changes. | |||
Techniques: | |||
*DNA sequencing - RT-PCR. | |||
*RNA sequencing. | |||
===Cytogenetics=== | |||
General: | |||
*Large changes (chromosomal). | |||
Techniques: | |||
*ISH = in situ hybridization. | |||
**FISH = fluorescent in situ hybridization. | |||
**SISH = silver in situ hybridization.<ref>URL: [http://www.immunoportal.com/modules.php?name=News&file=article&sid=186 http://www.immunoportal.com/modules.php?name=News&file=article&sid=186]. Accessed on: 2 May 2011.</ref> | |||
Image: | |||
*[http://commons.wikimedia.org/wiki/File:Bcrablmet.jpg Bcr-Abl translocation (WC)]. | |||
==World protein databank== | ==World protein databank== | ||
Revision as of 15:04, 2 May 2011
Molecular pathology is the future of pathology.
Overview
Molecular pathology can be divided as follows:
| Molecular pathology | |||||||||||||||||||
| Molecular | Cytogenetics | ||||||||||||||||||
Molecular
General:
- Very small changes.
Techniques:
- DNA sequencing - RT-PCR.
- RNA sequencing.
Cytogenetics
General:
- Large changes (chromosomal).
Techniques:
- ISH = in situ hybridization.
- FISH = fluorescent in situ hybridization.
- SISH = silver in situ hybridization.[1]
Image:
World protein databank
I can't help think it is ironic that the protein databank goal is to maintain a free and publicly available archive,[2] yet the announcement is in pay-for-access journal (Nature Structual Biology).[3]
Wnt/beta-catenin pathway
Important in hepatoblastomas.[4]
See also
References
- ↑ URL: http://www.immunoportal.com/modules.php?name=News&file=article&sid=186. Accessed on: 2 May 2011.
- ↑ Worldwide Protein Data Bank. URL: http://www.wwpdb.org/faq.html Accessed on: April 22, 2009.
- ↑ Berman H, Henrick K, Nakamura H (December 2003). "Announcing the worldwide Protein Data Bank". Nat. Struct. Biol. 10 (12): 980. doi:10.1038/nsb1203-980. PMID 14634627.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 923. ISBN 0-7216-0187-1.