Difference between revisions of "Placental alkaline phosphatase"

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{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      = ITGCN and Sertoli cells only - PLAP -- high mag.jpg
| Width      =
| Caption    = PLAP in [[germ cell neoplasia in situ]] - left of image. (WC)
| Abbrev    = PLAP
| Synonyms  =
| Similar    = OCT4, OCT3/4
| Clones    =     
| Use        = [[germ cell tumours]]
| Subspecial = [[genitourinary pathology]], [[gynecologic pathology]] 
| Pattern    = membranous
| Positive  = [[germ cell neoplasia in situ]] (previously ITGCN), [[seminoma]], [[embryonal carcinoma]]
| Negative  =
| Other      =
}}
'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]].
'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]].



Revision as of 19:03, 8 January 2017

Placental alkaline phosphatase
Immunostain in short

PLAP in germ cell neoplasia in situ - left of image. (WC)
Abbreviation PLAP
Similar stains OCT4, OCT3/4
Use germ cell tumours
Subspeciality genitourinary pathology, gynecologic pathology
Normal staining pattern membranous
Positive germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma

Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.

It has largely been replaced by OCT4.

Negative

Positive

See also

References

  1. Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
  2. Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.