Difference between revisions of "Small bowel pseudomelanosis"
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Revision as of 18:45, 22 March 2016
Pseudomelanosis duodeni is benign change of the duodenum that mimics melanin deposition.
It is also described in stomach and jejunum.[1]
General
- Rare.
- Consists of iron and lipofuscin.[2]
Associations:[3]
- Hypertension ~90% of cases.
- Iron supplementation ~75% of cases.
- End-stage renal disease ~60% of cases.
Note:
- The associations are different than for melanosis coli.
Gross/endoscopic
- Dark spots ~35% of cases.[3]
Microscopic
Features:
- Dark pigment in the lamina propria macrophages.
Images:
Stains
- Prussian blue +ve ~80% of cases.[3]
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Small bowel
A. Stomach, Partial Excision as Part of a Sleeve Gastrectomy: - Stomach wall within normal limits. B. Small Bowel Wall, Partial Excision as Part of a Sleeve Gastrectomy: - Small bowel wall with iron containing macrophages in the mucosa, known as "pseudomelanosis", see comment. - NEGATIVE for active inflammation. - NEGATIVE for dysplasia and NEGATIVE for malignancy. Comment: Pseudomelanosis may be seen in the context of iron supplementation, hypertension and chronic renal failure. The macrophages are positive with an iron stain.
See also
References
- ↑ Rustagi, T.; Mansoor, MS.; Gibson, JA.; Kapadia, CR. (Feb 2015). "Pseudomelanosis of stomach, duodenum, and jejunum.". J Clin Gastroenterol 49 (2): 124-6. doi:10.1097/MCG.0000000000000081. PMID 24492404.
- ↑ Lin, HJ.; Tsay, SH.; Chiang, H.; Tsai, YT.; Lee, SD.; Yeh, YS.; Lo, GH. (Apr 1988). "Pseudomelanosis duodeni. Case report and review of literature.". J Clin Gastroenterol 10 (2): 155-9. PMID 2458404.
- ↑ 3.0 3.1 3.2 Giusto, D.; Jakate, S. (Feb 2008). "Pseudomelanosis duodeni: associated with multiple clinical conditions and unpredictable iron stainability - a case series.". Endoscopy 40 (2): 165-7. doi:10.1055/s-2007-995472. PMID 18253910.