Difference between revisions of "Diffuse large B-cell lymphoma"

From Libre Pathology
Jump to navigation Jump to search
Line 22: Line 22:
*[[Follicular lymphoma]].
*[[Follicular lymphoma]].
**If a nodular architecture is present it is follicular lymphoma.
**If a nodular architecture is present it is follicular lymphoma.
*Post-transplant lymphoproliferative disorder (PTLD) - in organ transplant recipients.


==IHC==
==IHC==

Revision as of 15:36, 3 March 2011

Diffuse large B cell lymphoma, abbreviated DLBCL, is a very common lymphoma.

Microscopic

Features:[1]

  • Large lymphoid cells:
    • 4-5x the diameter of a small lymphocytes.
    • Marked cell-to-cell variation in size and shape.
    • Cytoplasm usually basophilic and moderate in abundance.
    • +/-Prominent nucleoli, may be peripheral and/or multiple.
  • Not follicular - nodular arrangement.

Notes:

  • Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in Hodgkin lymphoma.

Images:

Differential diagnosis

  • Carcinoma.
  • Anaplastic large cell lymphoma (ALCL).
  • Follicular lymphoma.
    • If a nodular architecture is present it is follicular lymphoma.
  • Post-transplant lymphoproliferative disorder (PTLD) - in organ transplant recipients.

IHC

"UHN panel"

  • H&E 2 micrometers.
  • CD20 -- B cells.
  • CD10 -- follicular lymphoma.
  • BCL6 -- follicular lymphoma.
  • BCL2 -- follicular lymphoma.
  • MUM1 -- B cells.
  • CD21 -- highlight FDC networks if present.
  • CD23 -- highlight FDC networks if present.
  • MIB1 -- proliferative rate.
  • EBER -- EBV.
  • CD3 -- T cells.
  • CD5 -- T cells.
  • Unstained x4.

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 676 (???). ISBN 0-7216-0187-1.
Retrieved from "https://librepathology.org/w/index.php?title=Diffuse_large_B-cell_lymphoma&oldid=4279"