Difference between revisions of "Fibrosing pleuritis"

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==Gross==
==Gross==
*Pleural thickening associated with a pleural effusion.
*Pleural thickening associated with a [[pleural effusion]].


==Microscopic==
==Microscopic==

Revision as of 18:54, 15 November 2015

Fibrosing pleuritis, also fibrous pleurisy, is an uncommon benign condition that mimics malignant mesothelioma.

It may be referred to as cryptogenic bilateral fibrosing pleuritis, if it is bilateral.

General

  • Benign.
  • No asbestos exposure.[1]

Clinical:[1]

Gross

Microscopic

Features:[citation needed]

  • Fibrosis.
    • Spindle cells.
    • Moderate cellularity.
  • No necrosis.[2]
  • Inflammation - lymphocytes.[1]

DDx:[3]

IHC

  • p53 -ve/+ve.
    • More common in mesothelioma.[2]

See also

References

  1. 1.0 1.1 1.2 Buchanan, DR.; Johnston, ID.; Kerr, IH.; Hetzel, MR.; Corrin, B.; Turner-Warwick, M. (Apr 1988). "Cryptogenic bilateral fibrosing pleuritis.". Br J Dis Chest 82 (2): 186-93. PMID 3166932.
  2. 2.0 2.1 Mangano, WE.; Cagle, PT.; Churg, A.; Vollmer, RT.; Roggli, VL. (Aug 1998). "The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.". Am J Clin Pathol 110 (2): 191-9. PMID 9704618.
  3. Corson, JM. (Nov 2004). "Pathology of mesothelioma.". Thorac Surg Clin 14 (4): 447-60. doi:10.1016/j.thorsurg.2004.06.007. PMID 15559051.