Difference between revisions of "Pulmonary carcinoid tumourlet"
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**Essentially a small [[typical carcinoid lung tumour|typical carcinoid]]. | **Essentially a small [[typical carcinoid lung tumour|typical carcinoid]]. | ||
*Arise from ''Kulchitsky cells'' of the bronchial epithelium.<ref name=pmid9064089>{{Cite journal | last1 = Ramón Capilla | first1 = M. | last2 = Arnau Obrer | first2 = A. | last3 = Navarro Ibáñez | first3 = R. | last4 = Galbis Caravajal | first4 = J. | last5 = Traves Zapata | first5 = V. | last6 = Cantó Armengod | first6 = A. | title = [Pulmonary tumorlet. Report of 5 cases]. | journal = Arch Bronconeumol | volume = 32 | issue = 9 | pages = 489-91 | month = Nov | year = 1996 | doi = | PMID = 9064089 }}</ref> | *Arise from ''Kulchitsky cells'' of the bronchial epithelium.<ref name=pmid9064089>{{Cite journal | last1 = Ramón Capilla | first1 = M. | last2 = Arnau Obrer | first2 = A. | last3 = Navarro Ibáñez | first3 = R. | last4 = Galbis Caravajal | first4 = J. | last5 = Traves Zapata | first5 = V. | last6 = Cantó Armengod | first6 = A. | title = [Pulmonary tumorlet. Report of 5 cases]. | journal = Arch Bronconeumol | volume = 32 | issue = 9 | pages = 489-91 | month = Nov | year = 1996 | doi = | PMID = 9064089 }}</ref> | ||
*May be seen in the context of [[diffuse idiopathic pulmonary neuroendocrine cell hyperplasia]]. | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 13:31, 25 September 2015
| Pulmonary carcinoid tumourlet | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | carcinoid tumourlet |
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| LM | cells with salt and pepper chromatin, usually nested architecture, no necrosis, minimal mitotic activity (see below) |
| LM DDx | typical carcinoid lung tumour, atypical lung carcinoid tumour |
| IHC | Ki-67 ~2% (0-7%) |
| Gross | <5 mm by definition |
| Site | lung - see lung tumours |
|
| |
| Clinical history | often an incidental finding |
| Prevalence | not common |
| Prognosis | benign |
Pulmonary carcinoid tumourlet, also carcinoid tumourlet, is a small benign proliferation of Kulchitsky cells.
The entity is separated from the typical lung carcinoid tumour by size. Carcinoid tumourlets are < 5 mm, typical lung carcinoid tumours are >=5 mm.
General
- Neuroendocrine cell proliferation.[1]
- Essentially a small typical carcinoid.
- Arise from Kulchitsky cells of the bronchial epithelium.[2]
- May be seen in the context of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Microscopic
Features:
- Nests of cells - classic pattern.
- Salt and pepper chromatin - key feature.
- Size criterion: <5 mm.[3][4]
DDx:
Images
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A. Lymph Node, Station 4R, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. B. Lymph Node, Station 11R, Lymphadenectomy: - Lymph node, NEGATIVE for malignancy. C. Lung, Right Middle Lobe, Lobectomy: - Typical carcinoid tumour (13 mm maximal dimension). - Carcinoid tumourlet (3 mm maximal dimension). - Margins clear of tumour. - Please see tumour summary.
See also
References
- ↑ Bennett, GL.; Chew, FS. (Mar 1994). "Pulmonary carcinoid tumorlets.". AJR Am J Roentgenol 162 (3): 568. PMID 8109497.
- ↑ Ramón Capilla, M.; Arnau Obrer, A.; Navarro Ibáñez, R.; Galbis Caravajal, J.; Traves Zapata, V.; Cantó Armengod, A. (Nov 1996). "[Pulmonary tumorlet. Report of 5 cases].". Arch Bronconeumol 32 (9): 489-91. PMID 9064089.
- ↑ URL: http://pathhsw5m54.ucsf.edu/case7/image75.html. Accessed on: 23 January 2012.
- ↑ He, P.; Gu, X.; Wu, Q.; Lin, Y.; Gu, Y.; He, J. (Dec 2012). "Pulmonary carcinoid tumorlet without underlying lung disease: analysis of its relationship to fibrosis.". J Thorac Dis 4 (6): 655-8. doi:10.3978/j.issn.2072-1439.2012.06.11. PMID 23205296.