Difference between revisions of "Endocervical adenocarcinoma in situ"

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===Images===
===Images===
====Case - ECC====
<gallery>
<gallery>
Image: Endocervical adenocarcinoma in situ -- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ -- intermed mag.jpg | AIS - intermed. mag.
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Image: Endocervical adenocarcinoma in situ 2a -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2a -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2b -- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ 2b -- very high mag.jpg | AIS - very high mag.
</gallery>
====Case - biopsy====
<gallery>
Image: Endocervical adenocarcinoma in situ --- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ --- high mag.jpg | AIS - high mag.
Image: Endocervical adenocarcinoma in situ --- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ - alt --- intermed mag.jpg | AIS - intermed. mag.
Image: Endocervical adenocarcinoma in situ - alt --- high mag.jpg | AIS - high mag.
Image: Endocervical adenocarcinoma in situ - alt --- very high mag.jpg | AIS - very high mag.
Image: Endocervical adenocarcinoma in situ - p16 --- intermed mag.jpg | AIS - p16 - intermed. mag.
Image: Endocervical adenocarcinoma in situ - p16 --- high mag.jpg | AIS - p16 - high mag.
Image: Endocervical adenocarcinoma in situ - p16 --- very high mag.jpg | AIS - p16 - very high mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- intermed mag.jpg | AIS - Ki-67 - intermed. mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- high mag.jpg | AIS - Ki-67 - high mag.
Image: Endocervical adenocarcinoma in situ - ki67 --- very high mag.jpg | AIS - Ki-67 - very high mag.
</gallery>
</gallery>
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Revision as of 14:52, 5 June 2016

Endocervical adenocarcinoma in situ
Diagnosis in short

Endocervical adenocarcinoma in situ. H&E stain.
LM Nuclear changes (nuclear crowding/pseudostratification, nuclear enlargement (often cigar-shaped nuclei), coarse chromatin, small nucleolus or nucleoli), +/-mitoses, +/-reduced cytoplasmic mucin, preservation of glandular architecture
LM DDx tubal metaplasia, Arias-Stella reaction, endometriosis, lower uterine segment epithelium (esp. proliferative phase endometrium), endocervical adenocarcinoma, metastatic adenocarcinoma
IHC p16 +ve
Site uterine cervix - endocervical canal
Associated Dx squamous lesions (LSIL, HSIL)
Clinical history +/-HPV
Symptoms asymptomatic
Prevalence uncommon
Clin. DDx endocervical adenocarcinoma (invasive), endometrial carcinoma, squamous cervical lesions
Treatment typically LEEP
For the cytology see Endocervical adenocarcinoma in situ (cytology)

Endocervical adenocarcinoma in situ, also adenocarcinoma in situ of the uterine endocervix, is pre-invasive change of the uterine endocervix. It is closely tied to HPV infection.

If the context is clear, it may be referred to as adenocarcinoma in situ, abbreviated AIS.

General

  • Usually due to HPV.
  • May be found together with squamous neoplasias of the cervix.
  • AIS of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix.
  • Generally, definitely diagnosed with an endocervical curettage (ECC).

Gross

  • Not apparent at colposcopy.

Microscopic

Features:[1]

  1. Nuclear changes - key feature:
    • Variable nuclear stratification.
      • Nuclear crowding/pseudostratification.
    • Nuclear enlargement.
      • Often cigar-shaped nuclei.
    • Coarse chromatin.
    • Small nucleolus or nucleoli.
  2. +/-Mitoses.
  3. +/-Reduced cytoplasmic mucin.
  4. Preservation of glandular architecture.
    • Normal gland spacing - lack of complexity ("lobular pattern").
    • Normal gland depth (subjective).

DDx:

Images

Case - ECC

  • AIS - intermed. mag.

  • AIS - high mag.

  • AIS - very high mag.

  • AIS - intermed. mag.

  • AIS - high mag.

  • AIS - very high mag.

  • AIS - very high mag.

Case - biopsy

  • AIS - intermed. mag.

  • AIS - high mag.

  • AIS - very high mag.

  • AIS - intermed. mag.

  • AIS - high mag.

  • AIS - very high mag.

  • AIS - p16 - intermed. mag.

  • AIS - p16 - high mag.

  • AIS - p16 - very high mag.

  • AIS - Ki-67 - intermed. mag.

  • AIS - Ki-67 - high mag.

  • AIS - Ki-67 - very high mag.

www

IHC

  • p16 +ve.
  • CEA +ve.
  • Vimentin -ve.

Sign out

UTERINE CERVIX, BIOPSY:
- HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (HSIL).
- ENDOCERVICAL ADENOCARCINOMA IN SITU (AIS).
- ACUTE AND CHRONIC INFLAMMATION.

COMMENT:
A p16 immunostain marks the full thickness of the squamous epithelium and is 
strong. A Ki-67 immunostain marks increased numbers of superficial squamous cells.

The atypical endocervical epithelium (interpreted as AIS) is strongly p16 positive 
and has an increased proliferative activity with Ki-67 staining.

Micro

The atypical endocervical epithelium (interpreted as AIS) shows marked hyperchromasia, nuclear crowding and moderate nuclear atypia with a relatively abundant cytoplasm ( nucleus to cell size = 1:2 ).

See also

References

  1. ↑ Zaino, RJ. (Mar 2000). "Glandular lesions of the uterine cervix.". Mod Pathol 13 (3): 261-74. doi:10.1038/modpathol.3880047. PMID 10757337. http://www.nature.com/modpathol/journal/v13/n3/full/3880047a.html.
  2. ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 167. ISBN 978-0443069208.
  3. ↑ URL: http://www.womenshealthsection.com/content/print.php3?title=gynpc006&cat=60&lng=english. Accessed on: 20 March 2013.
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