Difference between revisions of "Small vessel leukocytoclastic vasculitis"

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Line 7: Line 7:
| Micro      = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)
| Micro      = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)
| Subtypes  =
| Subtypes  =
| LMDDx      = fungal infection
| LMDDx      = [[dermatitides with perivascular inflammation]]
| Stains    = PAS -ve
| Stains    = [[PAS stain|PAS]] -ve
| IHC        =
| IHC        =
| EM        =
| EM        =

Revision as of 03:38, 14 August 2015

Small vessel leukocytoclastic vasculitis
Diagnosis in short

Leukocytoclastic vasculitis. H&E stain.

LM small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition)
LM DDx dermatitides with perivascular inflammation
Stains PAS -ve
Site blood vessels - see vasculitides

Signs palpable purpura
Prevalence uncommon
Prognosis dependent on underlying cause

Small vessel leukocytoclastic vasculitis, also leukocytoclastic vasculitis (abbreviated LCV), is an inflammatory process of the small blood vessel.

General

  • Most common cutaneous vasculitis.[1]

Clinical:

  • Palpable purpura, usu. lower extremity.

Microscopic

Features:[1]

  • Small upper dermis vessels with:
    1. Neutrophils.
    2. Vessel damage: fibrin deposition (bright pink acellular stuff).

Has a very broad DDx:[1]

  1. Infectious:
  2. Vasculitic disorders:
  3. Other:

Image

Case

www

Stains

  • PAS - look for fungus.

See also

References

  1. 1.0 1.1 1.2 Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
  2. Kraft, DM.; Mckee, D.; Scott, C. (Aug 1998). "Henoch-Schönlein purpura: a review.". Am Fam Physician 58 (2): 405-8, 411. PMID 9713395.