Difference between revisions of "Small vessel leukocytoclastic vasculitis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Leukocytoclastic vasculitis -- high mag.jpg | |||
| Width = | |||
| Caption = Leukocytoclastic vasculitis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition) | |||
| Subtypes = | |||
| LMDDx = fungal infection | |||
| Stains = PAS -ve | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[blood vessels]] - see ''[[vasculitides]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = palpable purpura | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = dependent on underlying cause | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | '''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | ||
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*Small upper dermis vessels with: | *Small upper dermis vessels with: | ||
*#Neutrophils. | *#Neutrophils. | ||
*#*Fragmentation of | *#*Fragmentation of [[neutrophil]]s (leukocytoclasia). | ||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | *#Vessel damage: fibrin deposition (bright pink acellular stuff). | ||
| Line 31: | Line 62: | ||
#*Drugs. | #*Drugs. | ||
Image: | ===Image=== | ||
www: | |||
*[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | *[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | ||
*[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)]. | ||
==Stains== | ==Stains== | ||
*PAS - look for fungus. | *[[PAS stain|PAS]] - look for fungus. | ||
==See also== | ==See also== | ||
Revision as of 03:34, 14 August 2015
| Small vessel leukocytoclastic vasculitis | |
|---|---|
| Diagnosis in short | |
 Leukocytoclastic vasculitis. H&E stain. | |
|
| |
| LM | small vessels intramural inflammatory cells (neutrophils), vessel damage (fibrin deposition) |
| LM DDx | fungal infection |
| Stains | PAS -ve |
| Site | blood vessels - see vasculitides |
|
| |
| Signs | palpable purpura |
| Prevalence | uncommon |
| Prognosis | dependent on underlying cause |
Small vessel leukocytoclastic vasculitis, also leukocytoclastic vasculitis (abbreviated LCV), is an inflammatory process of the small blood vessel.
General
- Most common cutaneous vasculitis.[1]
Clinical:
- Palpable purpura, usu. lower extremity.
Microscopic
Features:[1]
- Small upper dermis vessels with:
- Neutrophils.
- Fragmentation of neutrophils (leukocytoclasia).
- Vessel damage: fibrin deposition (bright pink acellular stuff).
- Neutrophils.
Has a very broad DDx:[1]
- Infectious:
- Bacterial.
- Viral.
- Fungal.
- Vasculitic disorders:
- ANCA mediated vasculitides:
- Henoch–Schönlein purpura.[2]
- Urticarial vasculitis.
- Other:
- Connective tissue disease, e.g. mixed connective tissue disease, SLE, rheumatoid arthritis.
- Cryoglobulinemia - may be due to multiple myeloma, hepatitis C; have intravascular thrombi.
- Paraneoplastic.
- Drugs.
Image
www:
Stains
- PAS - look for fungus.
See also
References
- ↑ 1.0 1.1 1.2 Brinster, NK. (Nov 2008). "Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II).". Adv Anat Pathol 15 (6): 350-69. doi:10.1097/PAP.0b013e31818b1ac6. PMID 18948765.
- ↑ Kraft, DM.; Mckee, D.; Scott, C. (Aug 1998). "Henoch-Schönlein purpura: a review.". Am Fam Physician 58 (2): 405-8, 411. PMID 9713395.