Difference between revisions of "Urinary bladder xanthoma"

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'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the [[urinary bladder]]''', is a rare benign lesion of the bladder that occasionally may be clinically suspicious for malignancy.<ref name=pmid24810457>{{Cite journal  | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue =  | pages =  | month =  | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref>
'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the [[urinary bladder]]''' and '''bladder xanthoma''', is a rare benign lesion of the bladder that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal  | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue =  | pages =  | month =  | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref>


==General==
==General==
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*S-100 -ve  
*S-100 -ve  
**Positive in granular cell tumour.
**Positive in granular cell tumour.
==Sign out==
<pre>
Urinary Bladder Lesion, Transurethral Excision:
- Xanthoma, see comment.
COMMENT:
These lesions may be associated metabolic abnormalities. A lipid profile
should be considered. 
</pre>


==See also==
==See also==

Revision as of 16:29, 22 July 2015

Urinary bladder xanthoma, also xanthoma of the urinary bladder and bladder xanthoma, is a rare benign lesion of the bladder that occasionally may be clinically suspicious for malignancy.[1]

General

  • Rare.
  • Like other xanthomas may be associated with abnormal lipid profile.

Presentation:[2]

  • Hematuria.
  • Irritation.

Gross

Features:[2]

  • Flat lesion (patch or plaque) with ill-defined border, yellow.

Microscopic

Features:

  • Aggregate of foamy histiocytes in the lamina propria.[2]
  • No significant nuclear atypia.

DDx:[2]

IHC

  • CD68 +ve.
  • S-100 -ve
    • Positive in granular cell tumour.

Sign out

Urinary Bladder Lesion, Transurethral Excision:
- Xanthoma, see comment.

COMMENT:
These lesions may be associated metabolic abnormalities. A lipid profile 
should be considered.  

See also

References

  1. Hassouna, H.; Broome, JD.; Swalem, K.; Manikandan, R. (2014). "Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy.". BMJ Case Rep 2014. doi:10.1136/bcr-2014-203836. PMID 24810457.
  2. 2.0 2.1 2.2 2.3 Yu, DC.; Patel, P.; Bonert, M.; Carlson, K.; Yilmaz, A.; Paner, G.; Magi-Galluzzi, C.; Lopez-Beltran, A. et al. (Aug 2015). "Urinary bladder xanthoma: a multi-institutional series of 17 cases.". Histopathology 67 (2): 255-61. doi:10.1111/his.12647. PMID 25580863.