Difference between revisions of "Choroid plexus papilloma"
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[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Papillary tumour]] | |||
Revision as of 08:44, 29 April 2015
| Choroid plexus papilloma | |
|---|---|
| Diagnosis in short | |
 Choroid plexus papilloma H&E stain. | |
|
| |
| LM | Papillary epithelial structures. |
| LM DDx | metastatic papillary adenocarcinoma, ELST |
| IHC | Kir 7.1+ve, EAAT1+ve, GFAP+/-, S-100+/-, CK+/- |
| Site | all ventricles, cerebellopontine angle |
|
| |
| Symptoms | hydrocephalus |
| Prevalence | Children |
Choroid plexus papilloma is a benign neuropathology arising in the ventricles of the brain.
General
Features: [1]
- Low grade
- WHO grade I (ICD-O: 9390/1).
- WHO grade II - atypical choroid plexus papilloma (ICD-O: 9390/1).
- Less than 1% of all brain tumors.
- Approx. 10-20% of all tumors in the first year of life.
- Congenital tumors reported.
- Usu. laternal ventricle in kids.[2]
Gross
Features: [1]
- Adhere to ventricular walls.
- Circumscribed.
- Villous architecture.
- 50% lateral ventricles.
- 5% third ventricle.
- 40% fourth ventricle.
- 5% multiple tumors or cerebellopontine angle.
Microscopic
Features: [3]
- Simple epithelium.
- Papillae.
- Psammoma bodies.
- Rarely oncocytic changes, mucinous degeneration.
- Necrosis and brain invasion is uncommon.
- Atypical CPP: 2 or more mitoses /10 HPF.[4]
IHC
- CK7+ve.
- CK20-ve (typically).
- S-100+/-.
- EMA-ve.
- GFAP +/-.
- Kir 7.1+ve.
- EAAT1+ve.
Images
Choroid plexus papilloma can become quite large. (WC/marvin101)
Intraoperative smear of a choroid plexus papilloma. (WC/jensflorian)
Choroid plexus papilloma. (WC)
Elevated proliferative activity (MIB-1) in atypical CPP. (WC/marvin101)
www:
See also
References
- ↑ 1.0 1.1 The International Agency for Research on Cancer (Editors: Louis, D.N.; Ohgaki, H.; Wiestler, O.D.; Cavenee, W.K.) (2007). Pathology and Genetics of Tumours of Tumors of the Central Nervous System (IARC WHO Classification of Tumours) (4th ed.). Lyon: World Health Organization. pp. 82. doi:10.1007/s00401-007-0243-4. ISBN 978-9283224303.
- ↑ URL: http://emedicine.medscape.com/article/250795-overview. Accessed on: 3 June 2011.
- ↑ Menon, G.; Nair, SN.; Baldawa, SS.; Rao, RB.; Krishnakumar, KP.; Gopalakrishnan, CV.. "Choroid plexus tumors: an institutional series of 25 patients.". Neurol India 58 (3): 429-35. doi:10.4103/0028-3886.66455. PMID 20644273.
- ↑ Wrede, B.; Hasselblatt, M.; Peters, O.; Thall, PF.; Kutluk, T.; Moghrabi, A.; Mahajan, A.; Rutkowski, S. et al. (Dec 2009). "Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study.". J Neurooncol 95 (3): 383-92. doi:10.1007/s11060-009-9936-y. PMID 19543851.