Difference between revisions of "Subependymoma"
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==Molecular== | ==Molecular== | ||
*No consistent abberations | *Posterior fossa and spine: chr.6 alterations. | ||
*Supratentorial: No consistent abberations. | |||
==See also== | ==See also== | ||
Latest revision as of 14:00, 8 July 2020
| Subependymoma | |
|---|---|
| Diagnosis in short | |
 Subependymoma. H&E stain. | |
|
| |
| LM | microcysts with bluish material (give a spongy appearance at low magnification), clustering of nuclei cluster (described as "bundles of flowers"), bland nuclei |
| Site | brain - see neuropathology tumours |
|
| |
| Symptoms | +/-headache |
| Radiology | classically fourth ventricle |
| Prognosis | WHO grade I |
| Clin. DDx | other brain tumours - ependymoma, CNS lymphoma |
| Treatment | surgical excision |
Subependymoma is neuropathology tumour classically found in the fourth ventricle.
General
- Good prognosis - WHO Grade I (ICD-O 9383/1).
- Low-grade glial tumour of the middle-aged and elderly.[1]
- Formerly called subependymal (glomerate) astrocytoma
Clinical:[1]
- Slow growing.
- +/-Headaches.
- CSF obstructions.
- Tx: surgery.
Gross/radiology
- Classic location: fourth ventricle (50-60%).[2]
- Lateral ventricles (30-40% of all cases), rarely IIIrd ventricle, septum pellucideum and spinal cord
- Well-demarcated margin.
- Usu. completely within the ventricle; does not extend into brain (like ependymomas).
- May be hemorrhagic. [3]
- Usually less than 2cm in diameter.
- Incidentally found at autopsies.
Images
Subependymoma (AFIP)
Macroscopy (AFIP)
Microscopic
Features:[4]
- Microcysts with bluish material - give a spongy appearance at low magnification.
- Isomorphic nuclei cluster embedded into fibrillary matrix.
- Described as "bundles of flowers".
- Calcifications possible
- Combined subependymomas/classical cellular ependymomas (then grade II)
Negatives.
- No nuclear pleomorphism, no prominent nucleoli, no mitoses.
- Do not invade into brain.[1]
Images
www: Subependymoma (ouhsc.edu).[4]
Subependymoma - low mag. (WC/jensflorian)
Subependyoma - intermed. mag. (WC)
Subependymoma - high mag. (WC)
Subependymoma - high mag. (WC/Nephron)
Subependymoma - very high mag. (WC)
Subependymoma (AFIP)
DDx: Ependymoma
IHC
- GFAP+ve
- MIB-1 very low (1%)
- ATRX: no loss
- IDH1(R132H)-ve
Molecular
- Posterior fossa and spine: chr.6 alterations.
- Supratentorial: No consistent abberations.
See also
References
- ↑ 1.0 1.1 1.2 Castro-Castro, J.; Castro-Bouzas, D.; Prieto-Casal, PL.; Carcacia-Hermilla, ID.; Riu-Lloveras, M.; Castro-Gómez, JE. (Mar 2013). "[Subependymoma of the lateral ventricle. A case report].". Rev Neurol 56 (6): 332-6. PMID 23483468.
- ↑ Hoeffel, C.; Boukobza, M.; Polivka, M.; Lot, G.; Guichard, JP.; Lafitte, F.; Reizine, D.; Merland, JJ.. "MR manifestations of subependymomas.". AJNR Am J Neuroradiol 16 (10): 2121-9. PMID 8585504. http://www.ajnr.org/cgi/reprint/16/10/2121.
- ↑ Landriel, F.; Besada, C.; Migliaro, M.; Christiansen, S.; Goldschmidt, E.; Yampolsky, C.; Ajler, P. (2013). "Atypical hemorrhagic presentation of a fourth ventricle subependymoma: case report.". Neurol Med Chir (Tokyo) 53 (11): 828-31. PMID 24140775.
- ↑ 4.0 4.1 URL: http://moon.ouhsc.edu/kfung/jty1/Com05/Com501-2-Diss.htm. Accessed on: 2 June 2011.