Difference between revisions of "Dysembryoplastic neuroepithelial tumour"

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'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNET''',<ref name=pmid25311417>{{Cite journal  | last1 = Alexander | first1 = H. | last2 = Tannenburg | first2 = A. | last3 = Walker | first3 = DG. | last4 = Coyne | first4 = T. | title = Progressive dysembryoplastic neuroepithelial tumour. | journal = J Clin Neurosci | volume = 22 | issue = 1 | pages = 221-4 | month = Jan | year = 2015 | doi = 10.1016/j.jocn.2014.07.022 | PMID = 25311417 }}</ref> is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].
'''Dysembryoplastic neuroepithelial tumour''', abbreviated '''DNET'''<ref name=pmid25311417>{{Cite journal  | last1 = Alexander | first1 = H. | last2 = Tannenburg | first2 = A. | last3 = Walker | first3 = DG. | last4 = Coyne | first4 = T. | title = Progressive dysembryoplastic neuroepithelial tumour. | journal = J Clin Neurosci | volume = 22 | issue = 1 | pages = 221-4 | month = Jan | year = 2015 | doi = 10.1016/j.jocn.2014.07.022 | PMID = 25311417 }}</ref> and '''DNT''',<ref name=pmid24735014>{{Cite journal  | last1 = Matyja | first1 = E. | last2 = Grajkowska | first2 = W. | last3 = Kunert | first3 = P. | last4 = Marchel | first4 = A. | title = A peculiar histopathological form of dysembryoplastic neuroepithelial tumor with separated pilocytic astrocytoma and rosette-forming glioneuronal tumor components. | journal = Neuropathology | volume = 34 | issue = 5 | pages = 491-8 | month = Oct | year = 2014 | doi = 10.1111/neup.12124 | PMID = 24735014 }}</ref> is a rare [[neuropathology tumour]] that is associated with [[epilepsy]].


==General==
==General==

Revision as of 22:16, 16 February 2015

Dysembryoplastic neuroepithelial tumour, abbreviated DNET[1] and DNT,[2] is a rare neuropathology tumour that is associated with epilepsy.

General

  • Common tumour cause of drug resistant epilepsy.[3]
  • Paediatric population.

Gross/radiology

  • Temporal lobe.
  • Variable architecture:[4] cystic, solitary nodular, multinodular.

Microscopic

Features:[4]

  • Cells similar to oligodendrocytes:
    • Large central nuclei with indentations.
    • Multiple small nucleoli (common).
    • Clear cytoplasm.

DDx:

Images

  • DNT. (WC/Sbrandner)

www:

See also

References

  1. ↑ Alexander, H.; Tannenburg, A.; Walker, DG.; Coyne, T. (Jan 2015). "Progressive dysembryoplastic neuroepithelial tumour.". J Clin Neurosci 22 (1): 221-4. doi:10.1016/j.jocn.2014.07.022. PMID 25311417.
  2. ↑ Matyja, E.; Grajkowska, W.; Kunert, P.; Marchel, A. (Oct 2014). "A peculiar histopathological form of dysembryoplastic neuroepithelial tumor with separated pilocytic astrocytoma and rosette-forming glioneuronal tumor components.". Neuropathology 34 (5): 491-8. doi:10.1111/neup.12124. PMID 24735014.
  3. ↑ Cataltepe, O.; Turanli, G.; Yalnizoglu, D.; Topçu, M.; Akalan, N. (Apr 2005). "Surgical management of temporal lobe tumor-related epilepsy in children.". J Neurosurg 102 (3 Suppl): 280-7. doi:10.3171/ped.2005.102.3.0280. PMID 15881751.
  4. ↑ 4.0 4.1 4.2 O'Brien, DF.; Farrell, M.; Delanty, N.; Traunecker, H.; Perrin, R.; Smyth, MD.; Park, TS. (Dec 2007). "The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.". Br J Neurosurg 21 (6): 539-49. doi:10.1080/02688690701594817. PMID 18071981.
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