Difference between revisions of "TFEB-rearranged renal cell carcinoma"
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==Molecular== | ==Molecular== | ||
*t(6;11)(p21;q12) | *t(6;11)(p21;q12) MALAT1<ref>{{OMIM|607924}}</ref>/TFEB.<ref name=Ref_WMSP281>{{Ref WMSP|281}}</ref> | ||
==See also== | ==See also== | ||
Revision as of 06:55, 30 December 2014
Renal tumour with t(6;11) translocation, also t(6;11) renal cell carcinoma, is a rare kidney tumour seen primarily in children.
It also known as TFEB RCC.[1]
General
- Very rare - approximately 2 dozen reported cases as of 2014.[1][2]
- Lymph node metastases are common.
- Traditionally thought of as a pediatric tumour... but cases in adults are reported.[3][1]
Microscopic
Features:
- Hyaline material between nests.
- Large cells with clear to eosinophilic cytoplasm.
IHC
- HMB-45 +ve.[1]
Molecular
See also
References
- ↑ 1.0 1.1 1.2 1.3 Hora, M.; Urge, T.; Trávníček, I.; Ferda, J.; Chudáček, Z.; Vaněček, T.; Michal, M.; Petersson, F. et al. (2014). "MiT translocation renal cell carcinomas: two subgroups of tumours with translocations involving 6p21 [t (6; 11)] and Xp11.2 [t (X;1 or X or 17)].". Springerplus 3: 245. doi:10.1186/2193-1801-3-245. PMID 24877033.
- ↑ Argani, P.; Yonescu, R.; Morsberger, L.; Morris, K.; Netto, GJ.; Smith, N.; Gonzalez, N.; Illei, PB. et al. (Oct 2012). "Molecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrum.". Am J Surg Pathol 36 (10): 1516-26. doi:10.1097/PAS.0b013e3182613d8f. PMID 22892601.
- ↑ Ishihara, A.; Yamashita, Y.; Takamori, H.; Kuroda, N. (Sep 2011). "Renal carcinoma with (6;11)(p21;q12) translocation: Report of an adult case.". Pathol Int 61 (9): 539-45. doi:10.1111/j.1440-1827.2011.02711.x. PMID 21884304.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 607924
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 281. ISBN 978-0781765275.