Difference between revisions of "Enteropathy-associated T-cell lymphoma"
Jump to navigation
Jump to search
(+infobox) |
|||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Enteropathy-associated_T_cell_lymphoma_-_low_mag.jpg | | Image = Enteropathy-associated_T_cell_lymphoma_-_low_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Enteropathy-associated T cell lymphoma. [[H&E stain]]. | | Caption = Enteropathy-associated T cell lymphoma. [[H&E stain]]. | ||
| Line 37: | Line 37: | ||
*T cell lymphoma due to [[celiac sprue]]. | *T cell lymphoma due to [[celiac sprue]]. | ||
*Subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | *Subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | ||
==Gross== | |||
Features:<ref name=pmid24959225>{{Cite journal | last1 = Jiao | first1 = G. | last2 = Zheng | first2 = Z. | last3 = Jiang | first3 = K. | last4 = Zhang | first4 = J. | last5 = Wang | first5 = B. | title = Enteropathy-associated T-cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation. | journal = Oncol Lett | volume = 8 | issue = 1 | pages = 91-94 | month = Jul | year = 2014 | doi = 10.3892/ol.2014.2105 | PMID = 24959225 }}</ref> | |||
*Typically manifest as ulcers, fissures or plaques. † | |||
Notes: | |||
*† B-cell lymphomas are typically raised nodules.<ref name=pmid24959225/> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 08:03, 20 December 2014
| Enteropathy-associated T-cell lymphoma | |
|---|---|
| Diagnosis in short | |
 Enteropathy-associated T cell lymphoma. H&E stain. | |
|
| |
| Synonyms | enteropathy-type T-cell lymphoma |
|
| |
| LM | large or medium-sized lymphoid cells in the mucosa and submucosa |
| IHC | CD3 +ve, CD5 -ve, CD8 -ve/+ve, CD56 -ve/+ve, CD30 +ve |
| Site | duodenum |
|
| |
| Associated Dx | celiac disease |
| Clinical history | history of celiac disease |
| Prevalence | uncommon |
Enteropathy-associated T-cell lymphoma, abbreviated EATL, is an uncommon type of lymphoma associated with celiac disease.
It is also known as enteropathy-type T-cell lymphoma, abbreviated ETTL.
General
- T cell lymphoma due to celiac sprue.
- Subdivided into type I and type II.[1]
Gross
Features:[2]
- Typically manifest as ulcers, fissures or plaques. †
Notes:
- † B-cell lymphomas are typically raised nodules.[2]
Microscopic
Features:[3]
- Abundant large or medium-sized lymphoid cells in the mucosa and submucosa.
- Large-sized cells ~ 2x RBC diameter = type 1.
- Medium sized cells ~ 1.5x RBC diameter = type 2.
- Intestinal epithelium usually preserved.
DDx:
- Other types of lymphoma, e.g. DLBCL.
Image
EATL. (WC)
IHC
Features - type 1:[3]
- CD56 +ve.
- CD3 +ve.
- CD5 -ve.
- CD8 -ve/+ve.
- CD56 -ve/+ve.
- CD30 +ve.
See also
References
- ↑ Delabie J, et al (July 2011). "Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project". Blood 118 (148): 148.
- ↑ 2.0 2.1 Jiao, G.; Zheng, Z.; Jiang, K.; Zhang, J.; Wang, B. (Jul 2014). "Enteropathy-associated T-cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation.". Oncol Lett 8 (1): 91-94. doi:10.3892/ol.2014.2105. PMID 24959225.
- ↑ 3.0 3.1 3.2 Takeshita, M.; Nakamura, S.; Kikuma, K.; Nakayama, Y.; Nimura, S.; Yao, T.; Urabe, S.; Ogawara, S. et al. (Feb 2011). "Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan.". Histopathology 58 (3): 395-407. doi:10.1111/j.1365-2559.2011.03768.x. PMID 21323966.
- ↑ Chan, JK.; Chan, AC.; Cheuk, W.; Wan, SK.; Lee, WK.; Lui, YH.; Chan, WK. (Oct 2011). "Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression.". Am J Surg Pathol 35 (10): 1557-69. doi:10.1097/PAS.0b013e318222dfcd. PMID 21921780.