Difference between revisions of "Bizarre parosteal osteochondromatous proliferation"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Bone Bizzare Parosteal Osteochondromatous Proliferation MP2.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Bizarre parosteal osteochondromatous proliferation. [[H&E stain]]. | ||
| Synonyms = Nora lesion | | Synonyms = Nora lesion | ||
| Micro = | | Micro = disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone, proliferation of fibroblasts surrounds the bone/cartilage and occupies the intertrabecular spaces | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = periosteal [[chondrosarcoma]], periosteal [[chondroma]], low grade parosteal [[osteosarcoma]], [[osteochondroma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = hands | | Site = [[bone]] (see ''[[chondro-osseous tumours]]'') - hands and feet | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 25: | Line 25: | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = benign/locally aggressive | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Line 72: | Line 72: | ||
</gallery> | </gallery> | ||
www: | www: | ||
* | *[http://www.webpathology.com/slides-13/slides/Bone_BizarreParostealOsteochondromatousProlif_Xray.jpg BPOP - radiology (webpathology.com)]. | ||
*[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg BPOP] | *[http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg BPOP (pathologyoutlines.com)]. | ||
==Diagnostic categories== | ==Diagnostic categories== | ||
Revision as of 02:41, 30 November 2014
| Bizarre parosteal osteochondromatous proliferation | |
|---|---|
| Diagnosis in short | |
 Bizarre parosteal osteochondromatous proliferation. H&E stain. | |
|
| |
| Synonyms | Nora lesion |
|
| |
| LM | disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone, proliferation of fibroblasts surrounds the bone/cartilage and occupies the intertrabecular spaces |
| LM DDx | periosteal chondrosarcoma, periosteal chondroma, low grade parosteal osteosarcoma, osteochondroma |
| Site | bone (see chondro-osseous tumours) - hands and feet |
|
| |
| Prevalence | rare |
| Prognosis | benign/locally aggressive |
Bizarre parosteal osteochondromatous proliferation, also known as Nora lesion, is a distinctive rare lesion of the hand or foot.[1]
General
A distinctive osteochondromatous proliferation of hands and feet.
Population:
- Young adults.
- Typically age (years) 20s and 30s.[1]
Prognosis:
- Benign.
- Locally aggressive.
Location
- Hands and feet.
Radiology
- Marginated wide based bony growth projecting into the soft tissues.[2]
Gross
- Nodule covered with glistening cartilage.
Microscopic
Features:
- Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. *Proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.
DDx:
- Periosteal chondrosarcoma.
- Periosteal chondroma.
- Low grade parosteal osteosarcoma.
- Osteochondroma.
Images
Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.
A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.
Medium power
Medium power
Medium Power
High power
.JPG)
www:
Diagnostic categories
- Cartilaginous neoplasms.
- Osteocartilaginous neoplasms.
Molecular
- t(1:17)(q32;q21).[3]
Sign out
- BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
- APPROPRIATE MARGIN STATEMENT.
See also
References
- ↑ 1.0 1.1 Gruber, G.; Giessauf, C.; Leithner, A.; Zacherl, M.; Clar, H.; Bodo, K.; Windhager, R. (Dec 2008). "Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature.". Can J Surg 51 (6): 486-9. PMID 19057740.
- ↑ URL: http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation. Accessed on: 29 November 2014.
- ↑ Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.