Difference between revisions of "Plasmacytoid urothelial carcinoma"
Jump to navigation
Jump to search
(+infobox) |
|||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = plasmacytoid urothelial cell carcinoma | |||
| Micro = plasmacytoid morphology (abundant gray cytoplasm; eccentrically placed (usually round) nucleus), +/-mucous (common), usually with conventional urothelial carcinoma | |||
| Subtypes = subtype of [[urothelial carcinoma]] | |||
| LMDDx = [[plasma cell neoplasm]], [[signet ring cell carcinoma]], [[mucinous adenocarcinoma]] | |||
| Stains = | |||
| IHC = AE1/AE3 +ve, EMA +ve, CK7 +ve, CK20 +ve, CD138 +ve, p63 +ve/-ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urothelium]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-hematuria | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = | |||
| Tx = surgical excision, chemotherapy | |||
}} | |||
'''Plasmacytoid urothelial carcinoma''', also '''plasmacytoid urothelial cell carcinoma''', is a rare aggressive variant of [[urothelial carcinoma]]. | '''Plasmacytoid urothelial carcinoma''', also '''plasmacytoid urothelial cell carcinoma''', is a rare aggressive variant of [[urothelial carcinoma]]. | ||
| Line 13: | Line 44: | ||
**Eccentric nucleus - usually round, occasionally crescentic. | **Eccentric nucleus - usually round, occasionally crescentic. | ||
*+/-Mucous (common). | *+/-Mucous (common). | ||
DDx: | |||
*[[Plasma cell neoplasm]]. | |||
*[[Signet ring cell carcinoma]]. | |||
*[[Mucinous adenocarcinoma]]. | |||
===Images=== | ===Images=== | ||
Revision as of 06:03, 7 April 2015
| Plasmacytoid urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | plasmacytoid urothelial cell carcinoma |
|
| |
| LM | plasmacytoid morphology (abundant gray cytoplasm; eccentrically placed (usually round) nucleus), +/-mucous (common), usually with conventional urothelial carcinoma |
| Subtypes | subtype of urothelial carcinoma |
| LM DDx | plasma cell neoplasm, signet ring cell carcinoma, mucinous adenocarcinoma |
| IHC | AE1/AE3 +ve, EMA +ve, CK7 +ve, CK20 +ve, CD138 +ve, p63 +ve/-ve |
| Site | urothelium |
|
| |
| Signs | +/-hematuria |
| Prevalence | rare |
| Prognosis | poor |
| Treatment | surgical excision, chemotherapy |
Plasmacytoid urothelial carcinoma, also plasmacytoid urothelial cell carcinoma, is a rare aggressive variant of urothelial carcinoma.
General
Features:[1]
- Aggresive.
- Uncommon.
- Often associated with positive margins (relative to other urothelial carcinoma variants); spreads along fascial planes.[2]
Microscopic
Features:
- Plasmacytoid morphology:
- Abundant gray cytoplasm.
- Eccentric nucleus - usually round, occasionally crescentic.
- +/-Mucous (common).
DDx:
Images
IHC
Features:[3]
- AE1/AE3 +ve (16 +ve/16 cases).
- EMA +ve (16 +ve/16 cases).
- CK7 +ve (16 +ve/16 cases).
- CK20 +ve (16 +ve/16 cases).
- CD138 (15 +ve/16 cases).
- p63 (11 +ve/16 cases).
See also
References
- ↑ Qin, M.; Wang, G.; Sun, Y.; He, Q.. "Plasmacytoid urothelial carcinoma of the bladder.". Indian J Pathol Microbiol 57 (2): 320-2. doi:10.4103/0377-4929.134730. PMID 24943778.
- ↑ Kaimakliotis, HZ.; Monn, MF.; Cheng, L.; Masterson, TA.; Cary, KC.; Pedrosa, JA.; Foster, RS.; Koch, MO. et al. (May 2014). "Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes.". Urology 83 (5): 1112-6. doi:10.1016/j.urology.2013.12.035. PMID 24582117.
- ↑ Zhang, W.; Jiang, YX.; Liu, Y.; Yu, WJ.; Zhao, H.; Li, YJ. (Jul 2013). "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. PMID 24246859.