Difference between revisions of "Plasmacytoid urothelial carcinoma"
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*Aggresive. | *Aggresive. | ||
*Uncommon. | *Uncommon. | ||
*Often associated with positive [[surgical margin|margin]]s (relative to other | *Often associated with positive [[surgical margin|margin]]s (relative to other [[urothelial carcinoma]] variants); spreads along fascial planes.<ref name=pmid24582117>{{Cite journal | last1 = Kaimakliotis | first1 = HZ. | last2 = Monn | first2 = MF. | last3 = Cheng | first3 = L. | last4 = Masterson | first4 = TA. | last5 = Cary | first5 = KC. | last6 = Pedrosa | first6 = JA. | last7 = Foster | first7 = RS. | last8 = Koch | first8 = MO. | last9 = Bihrle | first9 = R. | title = Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes. | journal = Urology | volume = 83 | issue = 5 | pages = 1112-6 | month = May | year = 2014 | doi = 10.1016/j.urology.2013.12.035 | PMID = 24582117 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 06:26, 12 November 2014
Plasmacytoid urothelial carcinoma, also plasmacytoid urothelial cell carcinoma, is a rare aggressive variant of urothelial carcinoma.
General
Features:[1]
- Aggresive.
- Uncommon.
- Often associated with positive margins (relative to other urothelial carcinoma variants); spreads along fascial planes.[2]
Microscopic
Features:
- Plasmacytoid morphology:
- Abundant gray cytoplasm.
- Eccentric nucleus - usually round, occasionally crescentic.
- +/-Mucous (common).
Images
IHC
Features:[3]
- AE1/AE3 +ve (16 +ve/16 cases).
- EMA +ve (16 +ve/16 cases).
- CK7 +ve (16 +ve/16 cases).
- CK20 +ve (16 +ve/16 cases).
- CD138 (15 +ve/16 cases).
- p63 (11 +ve/16 cases).
See also
References
- ↑ Qin, M.; Wang, G.; Sun, Y.; He, Q.. "Plasmacytoid urothelial carcinoma of the bladder.". Indian J Pathol Microbiol 57 (2): 320-2. doi:10.4103/0377-4929.134730. PMID 24943778.
- ↑ Kaimakliotis, HZ.; Monn, MF.; Cheng, L.; Masterson, TA.; Cary, KC.; Pedrosa, JA.; Foster, RS.; Koch, MO. et al. (May 2014). "Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes.". Urology 83 (5): 1112-6. doi:10.1016/j.urology.2013.12.035. PMID 24582117.
- ↑ Zhang, W.; Jiang, YX.; Liu, Y.; Yu, WJ.; Zhao, H.; Li, YJ. (Jul 2013). "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. PMID 24246859.