Difference between revisions of "Mast cell"
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*CD117 +ve. | *CD117 +ve.<ref name=pmid25038510>{{Cite journal | last1 = Schmetzer | first1 = O. | last2 = Valentin | first2 = P. | last3 = Smorodchenko | first3 = A. | last4 = Domenis | first4 = R. | last5 = Gri | first5 = G. | last6 = Siebenhaar | first6 = F. | last7 = Metz | first7 = M. | last8 = Maurer | first8 = M. | title = A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs). | journal = J Immunol Methods | volume = | issue = | pages = | month = Jul | year = 2014 | doi = 10.1016/j.jim.2014.07.003 | PMID = 25038510 }}</ref> | ||
*CD34 +ve.<ref name=pmid22119830>{{Cite journal | last1 = Duşe | first1 = AO. | last2 = Ceauşu | first2 = RA. | last3 = Mezei | first3 = T. | last4 = Cîmpean | first4 = AM. | last5 = Gaje | first5 = P. | last6 = Ioniţă | first6 = H. | last7 = Jung | first7 = I. | title = Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density. | journal = Rom J Morphol Embryol | volume = 52 | issue = 3 Suppl | pages = 1091-6 | month = | year = 2011 | doi = | PMID = 22119830 }}</ref>{{fact}} | *CD34 +ve.<ref name=pmid22119830>{{Cite journal | last1 = Duşe | first1 = AO. | last2 = Ceauşu | first2 = RA. | last3 = Mezei | first3 = T. | last4 = Cîmpean | first4 = AM. | last5 = Gaje | first5 = P. | last6 = Ioniţă | first6 = H. | last7 = Jung | first7 = I. | title = Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density. | journal = Rom J Morphol Embryol | volume = 52 | issue = 3 Suppl | pages = 1091-6 | month = | year = 2011 | doi = | PMID = 22119830 }}</ref>{{fact}} | ||
Revision as of 19:03, 27 October 2014
The mast cell is an uncommonly cell that occasionally causes problems.
Microscopic
Features:
- Ovoid/round cell with moderate amount of gray granular cytoplasm.
- Nuclear ovoid/round.
- No obvious nucleolus.
- May be more abundant around blood vessels.
Notes:
- Lymphocyte vs. mast cell:
- Lymphocytes = round; mast cells = ovoid.
Images
www:
- Mastocytosis - low res. (jameswpattersonmd.com).
- Mastocytosis - bone marrow - several images (upmc.edu).
Mastocytosis - high mag. (WC)
Mastocytosis - very high mag. (WC)
Diseases
- Mastocytosis.
- Urticaria pigmentosa.
- Asthma.[1]
Conditions associated with the presence of mast cells
Stains
- Giemsa stain.
- Tyrosinase.[3] (???)
IHC
- CD117 +ve.[4]
- CD34 +ve.[5][citation needed]
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.
- ↑ Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.
- ↑ URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.
- ↑ Schmetzer, O.; Valentin, P.; Smorodchenko, A.; Domenis, R.; Gri, G.; Siebenhaar, F.; Metz, M.; Maurer, M. (Jul 2014). "A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs).". J Immunol Methods. doi:10.1016/j.jim.2014.07.003. PMID 25038510.
- ↑ Duşe, AO.; Ceauşu, RA.; Mezei, T.; Cîmpean, AM.; Gaje, P.; Ioniţă, H.; Jung, I. (2011). "Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.". Rom J Morphol Embryol 52 (3 Suppl): 1091-6. PMID 22119830.