Difference between revisions of "Bizarre parosteal osteochondromatous proliferation"
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'''Bizarre parosteal osteochondromatous proliferation''', also '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal | last1 = Gruber | first1 = G. | last2 = Giessauf | first2 = C. | last3 = Leithner | first3 = A. | last4 = Zacherl | first4 = M. | last5 = Clar | first5 = H. | last6 = Bodo | first6 = K. | last7 = Windhager | first7 = R. | title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. | journal = Can J Surg | volume = 51 | issue = 6 | pages = 486-9 | month = Dec | year = 2008 | doi = | PMID = 19057740 }}</ref> | '''Bizarre parosteal osteochondromatous proliferation''', also known as '''Nora lesion''', is a distinctive rare lesion of the hand or foot.<ref name=pmid19057740>{{Cite journal | last1 = Gruber | first1 = G. | last2 = Giessauf | first2 = C. | last3 = Leithner | first3 = A. | last4 = Zacherl | first4 = M. | last5 = Clar | first5 = H. | last6 = Bodo | first6 = K. | last7 = Windhager | first7 = R. | title = Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. | journal = Can J Surg | volume = 51 | issue = 6 | pages = 486-9 | month = Dec | year = 2008 | doi = | PMID = 19057740 }}</ref> | ||
==General== | ==General== | ||
Revision as of 23:53, 18 October 2014
| Bizarre parosteal osteochondromatous proliferation | |
|---|---|
| Diagnosis in short | |
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| Synonyms | Nora lesion |
| Site | hands, feet |
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| Prevalence | rare |
Bizarre parosteal osteochondromatous proliferation, also known as Nora lesion, is a distinctive rare lesion of the hand or foot.[1]
General
A distinctive osteochondromatous proliferation of hands and feet.
Population:
- Young adults.
- Typically age (years) 20s and 30s.[1]
Location
Hands and feet
Radiology
- Marginated wide based bony growth projecting into the soft tissues.[2]
Gross
- Nodule covered with glistening cartilage.
Microscopic
Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.
DDx:
- Periosteal chondrosarcoma.
- Periosteal chondroma.
- Low grade parosteal osteosarcoma.
- Osteochondroma.
Images
Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.
A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.
.JPG)
![[1]](http://www.webpathology.com/images/noimage.gif){kind=link}
![[2]](http://webpathology.com/images/noimage.gif){kind=link}
![[4]](http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg){kind=link}
Diangostic categories
- Cartilaginous neoplasms
- Osteocartilaginous neoplasms
Molecular
t(1:17)(q32;q21)[3]
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- BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
- APPROPRIATE MARGIN STATEMENT.
Prognosis
- Benign
- Locally aggressive
See also
- Pathology Outlines[5]
References
- ↑ 1.0 1.1 Gruber, G.; Giessauf, C.; Leithner, A.; Zacherl, M.; Clar, H.; Bodo, K.; Windhager, R. (Dec 2008). "Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature.". Can J Surg 51 (6): 486-9. PMID 19057740.
- ↑ http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation
- ↑ Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.