Difference between revisions of "Metaphyseal fibrous defect"

From Libre Pathology
Jump to navigation Jump to search
Line 42: Line 42:
*Rarely seen as a pathologic specimen (should not be biopsied).
*Rarely seen as a pathologic specimen (should not be biopsied).
*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>
*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref>
*Radiographic diagnosis.


Clinical history:
Clinical history:
Line 47: Line 48:
*Pathologic fracture.
*Pathologic fracture.


Prognosis:
Treatment:
*Ideally should not be biopsied.
*None (spontaneously resolve by ossification).
*Radiographically characteristic and benign.
**Diagnosis is part of the ''skeletal do not touch list''.<ref>URL: [http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1]. Accessed on: October 14, 2014.</ref>
*Ideally should not be treated or even biopsied.
*Spontaneously resolve by ossification.
*May resolve into a 'bone island'.


==Site==
Notes:
*Metaphysis of distal femur or proximal tibia (80%).
*May resolve into a ''bone island''.
 
Clinical DDx:
*''FOG MACHINES'' acronym for radiographically lytic bone lesions.<ref>URL: [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref>
 
==Gross==
*Firm, granular, brown to yellow to red.
 
Site:
*[[Metaphysis]] of distal femur or proximal tibia (80%).
*Cortical.
*Cortical.
*[[Metaphysis]].
*Metaphysis.
*Long bones.
*Long bones.
*Eccentric location.
*Eccentric location.
==Gross==
*Firm, granular, brown to yellow to red.


==Microscopic==
==Microscopic==
Line 73: Line 77:
DDx (microscopic):
DDx (microscopic):
*[[Giant cell tumour of bone]] - [[epiphysis|epiphyseal]] location, occurs in adults.
*[[Giant cell tumour of bone]] - [[epiphysis|epiphyseal]] location, occurs in adults.
 
*Other [[giant cell lesions]] of bone.
==Relevant Diagnostic Groups==
*[[Spindle cell lesion]]s of bone.
*Clinical
**FOG MACHINES - acronym for radiographically lytic bone lesions <ref>URL: [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref>
**'Skeletal do not touch list' <ref>URL: [http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1]. Accessed on: October 14, 2014.</ref>
*Pathologic
**Giant cell lesions of bone.
**Spindle cell lesions of bone.


==Images==
==Images==
Line 97: Line 95:


==IHC==
==IHC==
*Not relevant
*Not relevant.


==Molecular==
==Molecular==
*Not relevant
*Not relevant.


==Radiographic findings==
==Radiographic findings==
Line 107: Line 105:
==Sign out==
==Sign out==
<pre>
<pre>
BONE, CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.
BONE, CURETTAGE:  
- METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.
</pre>
</pre>


Line 117: Line 116:


==External links==
==External links==
*http://njms2.umdnj.edu/tutorweb/case8.htm
*[http://njms2.umdnj.edu/tutorweb/case8.htm A case of MFD (umdnj.edu)].
*http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html
*[http://radiopaedia.org/articles/fibrous-cortical-defect Fibrous cortical defect (radiopaedia.org)].
*http://radiopaedia.org/articles/fibrous-cortical-defect
*[http://radiopaedia.org/articles/non-ossifying-fibroma-1 Non-ossifying fibroma (radiopaedia.org)]/
*http://radiopaedia.org/articles/non-ossifying-fibroma-1


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Bone]]
[[Category:Bone]]

Revision as of 05:36, 17 October 2014

Metaphyseal fibrous defect
Diagnosis in short
Synonyms nonossifying fibroma, fibrous cortical defect, fibrous metaphyseal defect, fibroxanthoma of bone
LM DDx giant cell tumour of bone
Site metaphysis of bone - usu. lower extremity
Clinical history incidental radiograhic finding
Prevalence common
Radiology lucent defect
Prognosis benign
Treatment none

Metaphyseal fibrous defect, abbreviated MFD, is a common benign abnormality of the metaphysis, classically seen in children and young adults.

They are also known as fibrous cortical defect, fibrous metaphyseal defect, and fibroxanthoma of bone. Nonossifying fibroma is a larger lesion but otherwise identical.

General

  • Common.
  • Non-neoplastic.
  • Self-limited.
  • Skeletally immature individuals, children and adolescents.
  • Often small lesions discovered as an radiographic incidentaloma.
  • Rarely seen as a pathologic specimen (should not be biopsied).
  • May be seen in the context of Jaffe-Campanacci syndrome.[1]
  • Radiographic diagnosis.

Clinical history:

  • Incidental radiographic finding.
  • Pathologic fracture.

Treatment:

  • None (spontaneously resolve by ossification).
    • Diagnosis is part of the skeletal do not touch list.[2]

Notes:

  • May resolve into a bone island.

Clinical DDx:

  • FOG MACHINES acronym for radiographically lytic bone lesions.[3]

Gross

  • Firm, granular, brown to yellow to red.

Site:

  • Metaphysis of distal femur or proximal tibia (80%).
  • Cortical.
  • Metaphysis.
  • Long bones.
  • Eccentric location.

Microscopic

Features:

  • Spindle cells without cytologic atypia are arranged in a storiform pattern.
  • Scattered chronic inflammatory cells and benign giant cells.
  • Foam cells and hemosiderin deposition are present.
  • Mitoses are seen but cytologic atypia is absent.

DDx (microscopic):

Images

  • Metaphyseal fibrous defect - intermediate magnification.

  • Metaphyseal fibrous defect - high magnification.

www:

Stains

  • Not relevant.

IHC

  • Not relevant.

Molecular

  • Not relevant.

Radiographic findings

Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone

Sign out

BONE, CURETTAGE: 
- METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.

See also

References

  1. ↑ URL: http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome. Accessed on: October 14, 2014.
  2. ↑ URL: http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1. Accessed on: October 14, 2014.
  3. ↑ URL: http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic. Accessed on: October 14, 2014.

External links

Retrieved from "https://librepathology.org/w/index.php?title=Metaphyseal_fibrous_defect&oldid=34128"