Difference between revisions of "Desmoplasia"
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==Microscopic== | ==Microscopic== | ||
Features: | |||
*Increased stromal cellularity - '''key feature'''. | *Increased stromal cellularity - '''key feature'''. | ||
**Large (plump) spindle cells (fibroblasts) with relatively pale, large nuclei. | **Large (plump) spindle cells (fibroblasts) with relatively pale, large nuclei. | ||
Revision as of 19:30, 13 September 2014
Desmoplasia is the formation if fibrous connective tissue.[1] It is also known as the desmoplastic response, desmoplastic stroma, desmoplastic stromal response, and stromal response.
It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive carcinoma.
Microscopic
Features:
- Increased stromal cellularity - key feature.
- Large (plump) spindle cells (fibroblasts) with relatively pale, large nuclei.
- Edema - pale spaces between the cells - may be apparent at low power.[2]
DDx:
Images
Desmoplasia in a cecal adenocarcinoma. (WC/Nephron)
www:
See also
References
- ↑ URL: http://www.merriam-webster.com/medical/desmoplasia. Accessed on: 2 May 2013.
- ↑ Weedman Molavi, Diana (2008). The Practice of Surgical Pathology: A Beginner's Guide to the Diagnostic Process (1st ed.). Springer. pp. 15. ISBN 978-0387744858.
- ↑ URL: http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm. Accessed on: 2 May 2013.