Difference between revisions of "KRAS mutation"
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[[Image:Colonic mucinous adenocarcinoma - low mag.jpg|thumb|right|[[Micrograph]] showing mucinous carcinoma, a histology associated with KRAS mutations.]] | |||
'''KRAS mutation''' is a re-occuring theme in [[molecular pathology]]. KRAS is an [[oncogene]].<ref name=omim190070>{{OMIM|190070}}</ref> | '''KRAS mutation''' is a re-occuring theme in [[molecular pathology]]. KRAS is an [[oncogene]].<ref name=omim190070>{{OMIM|190070}}</ref> | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Typically [[mucinous carcinoma]]. | *Typically [[mucinous carcinoma]].<ref name=pmid25029118>{{Cite journal | last1 = Kadota | first1 = K. | last2 = Yeh | first2 = YC. | last3 = D'Angelo | first3 = SP. | last4 = Moreira | first4 = AL. | last5 = Kuk | first5 = D. | last6 = Sima | first6 = CS. | last7 = Riely | first7 = GJ. | last8 = Arcila | first8 = ME. | last9 = Kris | first9 = MG. | title = Associations between mutations and histologic patterns of mucin in lung adenocarcinoma: invasive mucinous pattern and extracellular mucin are associated with KRAS mutation. | journal = Am J Surg Pathol | volume = 38 | issue = 8 | pages = 1118-27 | month = Aug | year = 2014 | doi = 10.1097/PAS.0000000000000246 | PMID = 25029118 }}</ref> | ||
==See also== | ==See also== | ||
Revision as of 15:36, 6 September 2014
Micrograph showing mucinous carcinoma, a histology associated with KRAS mutations.
KRAS mutation is a re-occuring theme in molecular pathology. KRAS is an oncogene.[1]
General
Seen in:
Not seen in the context of:
- ALK rearrangements in non-small cell lung cancer.[3]
Implication
In the context of colorectal carcinoma:[4][5]
- Patient must have wild type KRAS to get drugs; KRAS mutation predicts resistance to cetuximab (Erbitux) and panitumumab (Vectibix).
Microscopic
Features:
- Typically mucinous carcinoma.[6]
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190070
- ↑ Monzon, FA.; Ogino, S.; Hammond, ME.; Halling, KC.; Bloom, KJ.; Nikiforova, MN. (Oct 2009). "The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer.". Arch Pathol Lab Med 133 (10): 1600-6. doi:10.1043/1543-2165-133.10.1600. PMID 19792050.
- ↑ Gainor, JF.; Varghese, AM.; Ou, SH.; Kabraji, S.; Awad, MM.; Katayama, R.; Pawlak, A.; Mino-Kenudson, M. et al. (Aug 2013). "ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer.". Clin Cancer Res 19 (15): 4273-81. doi:10.1158/1078-0432.CCR-13-0318. PMID 23729361.
- ↑ Dunn EF, Iida M, Myers RA, et al. (October 2010). "Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab". Oncogene. doi:10.1038/onc.2010.430. PMID 20956938.
- ↑ Di Nicolantonio F, Martini M, Molinari F, et al. (December 2008). "Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer". J. Clin. Oncol. 26 (35): 5705–12. doi:10.1200/JCO.2008.18.0786. PMID 19001320.
- ↑ Kadota, K.; Yeh, YC.; D'Angelo, SP.; Moreira, AL.; Kuk, D.; Sima, CS.; Riely, GJ.; Arcila, ME. et al. (Aug 2014). "Associations between mutations and histologic patterns of mucin in lung adenocarcinoma: invasive mucinous pattern and extracellular mucin are associated with KRAS mutation.". Am J Surg Pathol 38 (8): 1118-27. doi:10.1097/PAS.0000000000000246. PMID 25029118.