Difference between revisions of "Tubulocystic carcinoma of the kidney"
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| Synonyms = low-grade collecting duct carcinoma | | Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma | ||
| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | | Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | ||
| Subtypes = | | Subtypes = | ||
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It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref> | It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal | last1 = Amin | first1 = MB. | last2 = MacLennan | first2 = GT. | last3 = Gupta | first3 = R. | last4 = Grignon | first4 = D. | last5 = Paraf | first5 = F. | last6 = Vieillefond | first6 = A. | last7 = Paner | first7 = GP. | last8 = Stovsky | first8 = M. | last9 = Young | first9 = AN. | title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. | journal = Am J Surg Pathol | volume = 33 | issue = 3 | pages = 384-92 | month = Mar | year = 2009 | doi = 10.1097/PAS.0b013e3181872d3f | PMID = 19011562 }}</ref> | ||
In the Vancouver classification it is refered to as '''tubulocystic renal cell carcinoma'''.<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | |||
It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]]. | It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours|renal tumour]]. | ||
Revision as of 22:56, 8 October 2014
| Tubulocystic carcinoma of the kidney | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma |
|
| |
| LM | cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma |
| LM DDx | renal oncocytoma, cystic nephroma/mixed epithelial and stromal tumour, multilocular cystic renal cell carcinoma |
| IHC | CD10 +ve, RCC +ve, vimentin +ve, AMACR +ve |
| Gross | multicystic lesion (bubble wrap-like appearance) |
| Site | kidney |
|
| |
| Clinical history | typically male |
| Prevalence | very rare |
| Prognosis | good |
Tubulocystic carcinoma of the kidney, abbreviated TCCK, is a very rare kidney tumour.
It is also known as low-grade collecting duct carcinoma.[1]
In the Vancouver classification it is refered to as tubulocystic renal cell carcinoma.[2]
It should not be confused with collecting duct carcinoma, a very aggressive renal tumour.
General
- Not in the WHO classification of renal tumours - as of 2013.[3]
- Rare <1% - in a series of 615 cases.
- Males:Females ~ 7:1.[1]
- Prognosis - probably favourable.[1]
Gross
- Bubble wrap-like appearance - due to the cystic nature.[1]
Microscopic
Features:.[1]
- Cysts of variable size lined by a single layer of epithelium that has a:
- Cuboidal, flat, or hobnail morphology.
- Eosinophilic cytoplasm.
- Large nuclei with prominent nucleoli.
- +/-Fibrotic stroma.
DDx:
- Renal oncocytoma.
- Cystic nephroma/Mixed epithelial and stromal tumour.
- Multilocular cystic renal cell carcinoma.
Images
IHC
Features:[3]
- CD10 +ve.
- RCC +ve.
- Vimentin +ve.
- AMACR +ve.
- CK7 -ve/+ve (focally in 2/3 tumours[5]).
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Amin, MB.; MacLennan, GT.; Gupta, R.; Grignon, D.; Paraf, F.; Vieillefond, A.; Paner, GP.; Stovsky, M. et al. (Mar 2009). "Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma.". Am J Surg Pathol 33 (3): 384-92. doi:10.1097/PAS.0b013e3181872d3f. PMID 19011562.
- ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
- ↑ 3.0 3.1 Alexiev, BA.; Drachenberg, CB. (May 2013). "Tubulocystic carcinoma of the kidney: a histologic, immunohistochemical, and ultrastructural study.". Virchows Arch 462 (5): 575-81. doi:10.1007/s00428-013-1398-0. PMID 23525677.
- ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
- ↑ Zhang, SH.; Shi, SF.; Huang, SF.; Zhang, YN.; Zheng, YY.; Chen, GY. (Aug 2012). "[Clinical and pathologic features of tubulocystic carcinoma of kidney].". Zhonghua Bing Li Xue Za Zhi 41 (8): 543-6. PMID 23157747.