Difference between revisions of "Fibrous dysplasia"
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| Caption = Fibrous dysplasia. [[H&E stain]]. | | Caption = Fibrous dysplasia. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = osteitis fibrosa | ||
| Micro = woven bone with odd irregular shapes (often described as "chinese characters"), fibrous tissue around bone, no osteoblastic rimming | | Micro = woven bone with odd irregular shapes (often described as "chinese characters"), fibrous tissue around bone, no osteoblastic rimming | ||
| Subtypes = | | Subtypes = | ||
Revision as of 02:49, 26 February 2014
| Fibrous dysplasia | |
|---|---|
| Diagnosis in short | |
 Fibrous dysplasia. H&E stain. | |
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| Synonyms | osteitis fibrosa |
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| LM | woven bone with odd irregular shapes (often described as "chinese characters"), fibrous tissue around bone, no osteoblastic rimming |
| LM DDx | desmoplastic fibroma, low-grade fibrosarcoma, low-grade central osteosarcoma |
| Site | bone |
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| |
| Syndromes | McCune-Albright syndrome |
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| Prevalence | uncommon |
| Prognosis | benign |
Fibrous dysplasia, also osteitis fibrosa, is a rare disorder of bone that has a distinctive microscopic appearance.
General
Classification:
- Monostotic - one bone involved, ~80% of cases.
- Polyostotic - several bones involved, ~20% of cases.
- May be associated with McCune-Albright syndrome.
Microscopic
Features:[1]
- Woven bone with odd irregular shapes - key feature.
- Described as "chinese characters".[2]
- Fibrous tissue around bone.
Notes:
- No osteoblastic rimming.
DDx:
- Desmoplastic fibroma - has lamellar bone.
- Low grade fibrosarcoma.
- Low-grade central osteosarcoma.[3]
Images
Fibrous dysplasia - low mag. (WC/Nephron)
Fibrous dysplasia - intermed. mag. (WC/Nephron)
Fibrous dysplasia - high mag. (WC/Nephron)
www:
- Fibrous dysplasia of bone - high mag. (pathologypics.com).
- Fibrous dysplasia of bone - low mag. (pathologypics.com).
See also
- Bone.
References
- ↑ URL: http://www.pathologypics.com/pictview.aspx?id=104. Accessed on: 14 April 2011.
- ↑ URL: http://www.pathcases.com/bone_tumors_and_tumor.htm. Accessed on: 31 May 2011.
- ↑ Inwards, CY (2001). "Low-grade central osteosarcoma versus fibrous dysplasia". Pathology Case Reviews 6 (1): 22-27. http://journals.lww.com/pathologycasereviews/Fulltext/2001/01000/Low_Grade_Central_Osteosarcoma_Versus_Fibrous.5.aspx.