Difference between revisions of "Apocrine carcinoma of the breast"

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| Micro      = cells with prominent [[nucleoli]] - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells
| Micro      = cells with prominent [[nucleoli]] - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells
| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      = [[glycogen-rich clear cell carcinoma of the breast]]
| Stains    =
| Stains    =
| IHC        = AR +ve, [[GCDFP-15]] +ve, ER -ve, PR -ve
| IHC        = AR +ve, [[GCDFP-15]] +ve, ER -ve, PR -ve
Line 41: Line 41:
*Abundant granular eosinophilic cytoplasm.
*Abundant granular eosinophilic cytoplasm.
*Architecture like invasive ductal carcinomas ''no special type''.
*Architecture like invasive ductal carcinomas ''no special type''.
DDx:
*[[Glycogen-rich clear cell carcinoma of the breast]].


===Images===
===Images===

Revision as of 19:11, 14 February 2014

Apocrine carcinoma of the breast
Diagnosis in short

LM cells with prominent nucleoli - may be multiple, abundant granular eosinophilic cytoplasm, loss of basal cells
LM DDx glycogen-rich clear cell carcinoma of the breast
IHC AR +ve, GCDFP-15 +ve, ER -ve, PR -ve
Site breast - see invasive breast cancer

Prevalence uncommon

Apocrine carcinoma of the breast is a rare form of invasive breast cancer.

General

  • Need >=90% apocrine morphology.[1]

Microscopic

Features:[1]

  • Prominent nucleoli.
    • Often multiple.[2]
  • Abundant granular eosinophilic cytoplasm.
  • Architecture like invasive ductal carcinomas no special type.

DDx:

Images

www:

IHC

Smaller tumours classically:[3]

Usually:[1]

  • ER -ve.
  • PR -ve.

See also

References

  1. 1.0 1.1 1.2 O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066801.
  2. O'Malley, FP.; Bane, A. (Jan 2008). "An update on apocrine lesions of the breast.". Histopathology 52 (1): 3-10. doi:10.1111/j.1365-2559.2007.02888.x. PMID 18171412.
  3. Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.