Difference between revisions of "Uterine cervix with atrophic changes"
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| Micro = small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses | | Micro = small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[HSIL]] | | LMDDx = [[HSIL]], immature [[squamous metaplasia of the uterine cervix|squamous metaplasia]] | ||
| Stains = | | Stains = | ||
| IHC = p16 -ve, Ki-67 rare basal cells | | IHC = p16 -ve, Ki-67 rare basal cells | ||
| Line 48: | Line 48: | ||
DDx: | DDx: | ||
*[[HSIL]]. | *[[HSIL]]. | ||
*Immature [[squamous metaplasia of the uterine cervix|squamous metaplasia]].<ref name=pmid17824788/> | |||
===Images=== | ===Images=== | ||
| Line 67: | Line 68: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid17824788>{{Cite journal | last1 = Iaconis | first1 = L. | last2 = Hyjek | first2 = E. | last3 = Ellenson | first3 = LH. | last4 = Pirog | first4 = EC. | title = p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. | journal = Arch Pathol Lab Med | volume = 131 | issue = 9 | pages = 1343-9 | month = Sep | year = 2007 | doi = 10.1043/1543-2165(2007)131[1343:PAKIIA]2.0.CO;2 | PMID = 17824788 }}</ref> | |||
*p16 -ve. | *p16 -ve. | ||
*Ki-67 rare basal cells. | *Ki-67 rare basal cells. | ||
Revision as of 04:05, 18 January 2014
| Uterine cervix with atrophic changes | |
|---|---|
| Diagnosis in short | |
 Atrophic cervix. H&E stain. | |
|
| |
| LM | small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses |
| LM DDx | HSIL, immature squamous metaplasia |
| IHC | p16 -ve, Ki-67 rare basal cells |
| Site | uterine cervix - exocervix |
|
| |
| Clinical history | old |
| Prevalence | common |
| Prognosis | benign |
| Other | normal - postmenopausal |
Uterine cervix with atrophic changes is relatively common and is important to recognize as it can mimic HSIL.
It is also known as atrophy of the uterine cervix, cervical atrophy, atrophy of the cervix and cervix with atrophic changes.
General
- Common.
- Post-menupausal.
- Important to recognize and differentiate from HSIL.
Microscopic
Features:
- Cells smaller.
- Cytoplasm grey/blue.
- No "dancing"/"sparkling" chromatin.
- No mitoses.
DDx:
- HSIL.
- Immature squamous metaplasia.[1]
Images
AC - intermed. mag. (WC)
AC - high mag. (WC)
AC - high mag. (WC)
AC - very high mag. (WC)
AC - intermed. mag. (WC)
AC - high mag. (WC)
AC - very high mag. (WC)
www:
- Atrophic cervix (nih.techriver.net).
- Atrophic cervix (flickriver.com/euthman).
- Atrophic changes in the vagina (eurocytology.eu).[2]
IHC
Features:[1]
- p16 -ve.
- Ki-67 rare basal cells.
Sign out
UTERINE CERVIX, BIOPSY: - SQUAMOUS MUCOSA WITH ATROPHIC CHANGES. - BENIGN ENDOCERVICAL EPITHELIUM. - NEGATIVE FOR DYSPLASIA. COMMENT: A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells.
See also
References
- ↑ 1.0 1.1 Iaconis, L.; Hyjek, E.; Ellenson, LH.; Pirog, EC. (Sep 2007). "p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection.". Arch Pathol Lab Med 131 (9): 1343-9. doi:10.1043/1543-2165(2007)131[1343:PAKIIA]2.0.CO;2. PMID 17824788.
- ↑ URL: http://www.eurocytology.eu/static/eurocytology/TUR/cervical/LP1ContentLcontC.html. Accessed on: 13 December 2013.