Difference between revisions of "Endometrium with squamous morules"
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==General== | ==General== | ||
*Benign finding in itself. | *Benign finding in itself. | ||
*Strong association | *Strong association with malignancy.<ref name=pmid21126963>{{Cite journal | last1 = Nicolae | first1 = A. | last2 = Preda | first2 = O. | last3 = Nogales | first3 = FF. | title = Endometrial metaplasias and reactive changes: a spectrum of altered differentiation. | journal = J Clin Pathol | volume = 64 | issue = 2 | pages = 97-106 | month = Feb | year = 2011 | doi = 10.1136/jcp.2010.085555 | PMID = 21126963 }}</ref> | ||
**Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, ''not'' neoplastic squamous lesions.<ref>{{Cite journal | last1 = Lin | first1 = MC. | last2 = Lomo | first2 = L. | last3 = Baak | first3 = JP. | last4 = Eng | first4 = C. | last5 = Ince | first5 = TA. | last6 = Crum | first6 = CP. | last7 = Mutter | first7 = GL. | title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. | journal = Mod Pathol | volume = 22 | issue = 2 | pages = 167-74 | month = Feb | year = 2009 | doi = 10.1038/modpathol.2008.146 | PMID = 19180120 }}</ref> | **Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, ''not'' neoplastic squamous lesions.<ref>{{Cite journal | last1 = Lin | first1 = MC. | last2 = Lomo | first2 = L. | last3 = Baak | first3 = JP. | last4 = Eng | first4 = C. | last5 = Ince | first5 = TA. | last6 = Crum | first6 = CP. | last7 = Mutter | first7 = GL. | title = Squamous morules are functionally inert elements of premalignant endometrial neoplasia. | journal = Mod Pathol | volume = 22 | issue = 2 | pages = 167-74 | month = Feb | year = 2009 | doi = 10.1038/modpathol.2008.146 | PMID = 19180120 }}</ref> | ||
Revision as of 19:34, 18 December 2013
| Endometrium with squamous morules | |
|---|---|
| Diagnosis in short | |
 Squamous morule. H&E stain. | |
|
| |
| LM | well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus |
| LM DDx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma, uterine leiomyoma |
| Gross | +/-endometrial thickening |
| Site | endometrium |
|
| |
| Associated Dx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma |
| Prognosis | benign in itself, strong assoc. with malignancy |
Endometrium with squamous morules is important to recognize as squamous morules are strongly associated with malignancy.
General
- Benign finding in itself.
- Strong association with malignancy.[1]
- Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, not neoplastic squamous lesions.[2]
Microscopic
Features:
- Well-circumscribed ball of squamoid cells:
- Cells have a whorled arrangement.
- Moderate eosinophilic cytoplasm.
- Bland nucleus.
DDx:
- Complex endometrial hyperplasia with or without atypia.
- Endometrioid endometrial carcinoma.
- Uterine leiomyoma.
Images
SM - intermed. mag.
SM - high mag.
SM - high mag.
SM - high mag.
SM - very high mag.
SM - extremely high mag.
See also
References
- ↑ Nicolae, A.; Preda, O.; Nogales, FF. (Feb 2011). "Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.". J Clin Pathol 64 (2): 97-106. doi:10.1136/jcp.2010.085555. PMID 21126963.
- ↑ Lin, MC.; Lomo, L.; Baak, JP.; Eng, C.; Ince, TA.; Crum, CP.; Mutter, GL. (Feb 2009). "Squamous morules are functionally inert elements of premalignant endometrial neoplasia.". Mod Pathol 22 (2): 167-74. doi:10.1038/modpathol.2008.146. PMID 19180120.