Difference between revisions of "Endometrium with squamous morules"
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| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign in itself, strong assoc. with malignancy | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = |
Revision as of 19:32, 18 December 2013
Endometrium with squamous morules | |
---|---|
Diagnosis in short | |
Squamous morule. H&E stain. | |
| |
LM | well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus |
LM DDx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma, uterine leiomyoma |
Gross | +/-endometrial thickening |
Site | endometrium |
| |
Associated Dx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma |
Prognosis | benign in itself, strong assoc. with malignancy |
Endometrium with squamous morules is important to recognize as squamous morules are strongly associated with malignancy.
General
- Benign finding in itself.
- Strong association of with malignancy.[1]
- Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, not neoplastic squamous lesions.[2]
Microscopic
Features:
- Well-circumscribed ball of squamoid cells:
- Cells have a whorled arrangement.
- Moderate eosinophilic cytoplasm.
- Bland nucleus.
DDx:
- Complex endometrial hyperplasia with or without atypia.
- Endometrioid endometrial carcinoma.
- Uterine leiomyoma.
Images
See also
References
- ↑ Nicolae, A.; Preda, O.; Nogales, FF. (Feb 2011). "Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.". J Clin Pathol 64 (2): 97-106. doi:10.1136/jcp.2010.085555. PMID 21126963.
- ↑ Lin, MC.; Lomo, L.; Baak, JP.; Eng, C.; Ince, TA.; Crum, CP.; Mutter, GL. (Feb 2009). "Squamous morules are functionally inert elements of premalignant endometrial neoplasia.". Mod Pathol 22 (2): 167-74. doi:10.1038/modpathol.2008.146. PMID 19180120.