Difference between revisions of "Endometrium with squamous morules"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Squamous morule b - endometrium -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Squamous morule. [[H&E stain]]. | ||
| Micro = | | Micro = well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[endometrial hyperplasia]], [[endometrial carcinoma]] - esp. [[endometrioid endometrial carcinoma]], [[uterine leiomyoma]] | | LMDDx = [[endometrial hyperplasia]], [[endometrial carcinoma]] - esp. [[endometrioid endometrial carcinoma]], [[uterine leiomyoma]] | ||
| Line 39: | Line 39: | ||
*Well-circumscribed ball of squamoid cells: | *Well-circumscribed ball of squamoid cells: | ||
**Cells have a whorled arrangement. | **Cells have a whorled arrangement. | ||
**Moderate cytoplasm. | **Moderate eosinophilic cytoplasm. | ||
**Bland nucleus. | **Bland nucleus. | ||
Revision as of 19:32, 18 December 2013
| Endometrium with squamous morules | |
|---|---|
| Diagnosis in short | |
 Squamous morule. H&E stain. | |
|
| |
| LM | well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus |
| LM DDx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma, uterine leiomyoma |
| Gross | +/-endometrial thickening |
| Site | endometrium |
|
| |
| Associated Dx | endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma |
| Prognosis | benign |
Endometrium with squamous morules is important to recognize as squamous morules are strongly associated with malignancy.
General
- Benign finding in itself.
- Strong association of with malignancy.[1]
- Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, not neoplastic squamous lesions.[2]
Microscopic
Features:
- Well-circumscribed ball of squamoid cells:
- Cells have a whorled arrangement.
- Moderate eosinophilic cytoplasm.
- Bland nucleus.
DDx:
- Complex endometrial hyperplasia with or without atypia.
- Endometrioid endometrial carcinoma.
- Uterine leiomyoma.
Images
SM - intermed. mag.
SM - high mag.
SM - high mag.
SM - high mag.
SM - very high mag.
SM - extremely high mag.
See also
References
- ↑ Nicolae, A.; Preda, O.; Nogales, FF. (Feb 2011). "Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.". J Clin Pathol 64 (2): 97-106. doi:10.1136/jcp.2010.085555. PMID 21126963.
- ↑ Lin, MC.; Lomo, L.; Baak, JP.; Eng, C.; Ince, TA.; Crum, CP.; Mutter, GL. (Feb 2009). "Squamous morules are functionally inert elements of premalignant endometrial neoplasia.". Mod Pathol 22 (2): 167-74. doi:10.1038/modpathol.2008.146. PMID 19180120.