Difference between revisions of "Thrombotic thrombocytopenic purpura"
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#Thrombocytopenia. | #Thrombocytopenia. | ||
#Microangiopathic hemolytic anemia. | #Microangiopathic hemolytic anemia. | ||
#*Usu. with schistocytes (fragmented RBCs).<ref>{{Ref Klatt|65}}</ref> | |||
#Transient neurologic symptoms. | #Transient neurologic symptoms. | ||
#Renal failure. | #Renal failure. | ||
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*'''F'''ever. | *'''F'''ever. | ||
*'''T'''hrombocytopenia. | *'''T'''hrombocytopenia. | ||
*'''Y''' - no one knows "Y" it occurs. | *'''Y''' - no one knows "Y" it occurs. | ||
==Etiology== | ==Etiology== | ||
Revision as of 02:34, 14 November 2010
Thrombotic thrombocytopenic purpura is a type of thrombotic microangiopathy.
Classic pentad
It was classically described as the pentad of:[1]
- Fever.
- Thrombocytopenia.
- Microangiopathic hemolytic anemia.
- Usu. with schistocytes (fragmented RBCs).[2]
- Transient neurologic symptoms.
- Renal failure.
Mnemonic
HUS/TTP is a CRAFTY syndrome:[3]
- CNS symptoms.
- Renal failure.
- Anemia - microangiopathic hemolytic anemia.
- Fever.
- Thrombocytopenia.
- Y - no one knows "Y" it occurs.
Etiology
Deficiency of plasma enzyme ADAMTS13 which may be:[1]
- Inherited.
- Acquired (autoantibodies).
See also
References
- ↑ 1.0 1.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 669. ISBN 978-1416031215.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 65. ISBN 978-1416002741.
- ↑ URL: http://www.valuemd.com/mnemonics2.php. Accessed on: 8 November 2010.