Difference between revisions of "Scleroderma"
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==Associated pathology== | ==Associated pathology== | ||
*[[Scleroderma panniculitis]]. | *[[Scleroderma panniculitis]]. | ||
*Scleroderma renal crisis - see ''[[thrombotic microangiopathy]]''. | |||
*Digit ischemia - may require [[finger amputation]].<ref>{{Cite journal | last1 = Jones | first1 = NF. | last2 = Imbriglia | first2 = JE. | last3 = Steen | first3 = VD. | last4 = Medsger | first4 = TA. | title = Surgery for scleroderma of the hand. | journal = J Hand Surg Am | volume = 12 | issue = 3 | pages = 391-400 | month = May | year = 1987 | doi = | PMID = 3584887 }}</ref> | *Digit ischemia - may require [[finger amputation]].<ref>{{Cite journal | last1 = Jones | first1 = NF. | last2 = Imbriglia | first2 = JE. | last3 = Steen | first3 = VD. | last4 = Medsger | first4 = TA. | title = Surgery for scleroderma of the hand. | journal = J Hand Surg Am | volume = 12 | issue = 3 | pages = 391-400 | month = May | year = 1987 | doi = | PMID = 3584887 }}</ref> | ||
Latest revision as of 16:32, 5 August 2015
Scleroderma is a disease that keeps rheumatologists busy.
General
Clinical:
- Anti-centromere antibody (ACA) +ve.
- Common in limited systemic scleroderma, AKA CREST syndrome.
- Scl-70 (topoisomerase I) +ve.
- Common in diffuse scleroderma.
CREST syndrome:
- Calcinosis.
- Raynaud's phenomenon.
- Esophageal dysmotility.
- Sclerodactyly.
- Telangiectasia.
Associated pathology
- Scleroderma panniculitis.
- Scleroderma renal crisis - see thrombotic microangiopathy.
- Digit ischemia - may require finger amputation.[1]