Difference between revisions of "Endometrial stromal sarcoma"
Jump to navigation
Jump to search
(more) |
(more) |
||
| Line 33: | Line 33: | ||
==General== | ==General== | ||
* | *Uncommon.<ref name=pmid20179433> {{Cite journal | last1 = Chew | first1 = I. | last2 = Oliva | first2 = E. | title = Endometrial stromal sarcomas: a review of potential prognostic factors. | journal = Adv Anat Pathol | volume = 17 | issue = 2 | pages = 113-21 | month = Mar | year = 2010 | doi = 10.1097/PAP.0b013e3181cfb7c2 | PMID = 20179433 }}</ref> | ||
*Prognosis good.<ref name=pmid24146786></ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 47: | Line 48: | ||
Notes: | Notes: | ||
*Vaguely resembles the stroma of proliferative endometrium. | *Vaguely resembles the stroma of proliferative endometrium. | ||
*Low mitotic rate - predictive of good outcome.<ref name=pmid24146786/> | |||
DDx: | DDx: | ||
Revision as of 03:40, 17 November 2013
| Endometrial stromal sarcoma | |
|---|---|
| Diagnosis in short | |
 Endometrial stromal sarcoma. H&E stain. | |
|
| |
| LM | highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high NC ratio and epithelioid, pallisade around thin blood vessels within the tumour |
| LM DDx | leiomyoma (cellular), endometrial stromal nodule, Uterine leiomyosarcoma. |
| IHC | CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve |
| Molecular | t(7;17) |
| Site | uterus - see uterine tumours |
|
| |
| Prevalence | rare |
| Clin. DDx | other uterine tumours |
Endometrial stromal sarcoma, abbreviated ESS, is a rare malignant mesenchymal tumour of the uterus.
It is also known as low-grade endometrial stromal sarcoma
General
Microscopic
Features:
- Highly cellular islands with a wavy irregular border.
- Border has finger-like projections/tongue-like projections.
- Benign uterine smooth muscle between islands of tumour cells.
- Epithelioid cells.
- High NC ratio.
- Thin blood vessels within islands of cells.
- Tumour cells pallisade around the vessels.
Notes:
- Vaguely resembles the stroma of proliferative endometrium.
- Low mitotic rate - predictive of good outcome.[2]
DDx:
Images
ESS - low mag. (WC/Nephron)
ESS - low mag. (WC/Nephron)
ESS - intermed. mag. (WC/Nephron)
ESS - high mag. (WC/Nephron)
ESS - very high mag. (WC/Nephron)
ESS. (WC)
Endometrial stromal sarcoma - low grade. (WC)
www:
IHC
Features:[4]
- CD10 +ve.
- H-caldesmin -ve.
- Leiomyomas +ve.
- PR +/-ve.
- ER +/-ve.
Molecular
May be associated a recurrent translocation:[5]
See also
References
- ↑ Chew, I.; Oliva, E. (Mar 2010). "Endometrial stromal sarcomas: a review of potential prognostic factors.". Adv Anat Pathol 17 (2): 113-21. doi:10.1097/PAP.0b013e3181cfb7c2. PMID 20179433.
- ↑ 2.0 2.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid24146786 - ↑ Baker, P.; Oliva, E. (Mar 2007). "Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques.". J Clin Pathol 60 (3): 235-43. doi:10.1136/jcp.2005.031203. PMID 17347285. http://jcp.bmj.com/content/60/3/235.full.
- ↑ Zhu, XQ.; Shi, YF.; Cheng, XD.; Zhao, CL.; Wu, YZ. (Jan 2004). "Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma.". Gynecol Oncol 92 (1): 71-9. PMID 14751141.
- ↑ Amant, F.; Moerman, P.; Cadron, I.; Hagemeijer, A.; Vergote, I.; Debiec-Rychter, M. (Mar 2003). "Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature.". Gynecol Oncol 88 (3): 459-62. PMID 12648605.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 606246
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 606245