Talk:Neuropathology tumours

Glioblastoma

Microscopic

Sections show an infiltrating tumour composed of randomly arranged cells of astroglial origin, as shown by their eosinophilic cytoplasm drawn into processes. There is marked nuclear pleomorphism, abundant mitotic activity, vigorous microvascular proliferation and extensive areas of necrosis with pseudopalisading of tumour.

Final diagnosis

BRAIN:
-GLIOBLASTOMA (WHO GRADE IV).

Meningioma

Microscopic

The microscopic section/sections shows a moderately cellular with lesion with prominent whorls, thick-walled blood vessels and focal calcifications.

There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have a high nuclear-to-cytoplasmic ratio.

Final diagnosis

MENINGIOMA, GRADE 1.

Anaplastic astrocytoma

Microscopic

The microscopic section/sections shows white matter with tumour. The tumour cell nuclei are oblong and have a marked irregular profile and occasionally eosinophilic cytoplasm. Mitoses are rare/common. There is no necrosis and no microvascular proliferation. Immunohistochemistry shows GFAP staining of the perikaryon in cytologically malignant cells. Occasional/Many/All tumour cells stain for p53. The Ki-67 is positive in approximately X% of tumour cells.

Final diagnosis

ANAPLASTIC ASTROCYTOMA, WHO GRADE 3.

Oligodendroglioma

Microscopic

The microscopic section/sections shows regularly distributed cells with round nuclei that are surrounded by clear halos. No mitoses are present. Microvascular proliferation is not seen. The nuclear atypia is mild-to-moderate. There is no nuclear overlapping.

Final diagnosis

OLIGODENDROGLIOMA, WHO GRADE 2.