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Difference between revisions of "Colorectal tumours"
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→Mismatch repair pathway
m (→KRAS mutation) |
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**Lost in nuclei of tumour. | **Lost in nuclei of tumour. | ||
*Mutations in MSH2 more often associated with a germline mutation, while mutation in MLH1 are usually sporatic. | *Mutations in MSH2 more often associated with a germline mutation, while mutation in MLH1 are usually sporatic. | ||
**PMS2 mutation (IHC stain -ve) are often germline associated.<ref name=pmid20205264>{{cite journal |author=Vaughn CP, Robles J, Swensen JJ, ''et al.'' |title=Clinical analysis of PMS2: mutation detection and avoidance of pseudogenes |journal=Hum. Mutat. |volume=31 |issue=5 |pages=588–93 |year=2010 |month=May |pmid=20205264 |doi=10.1002/humu.21230 |url=}}</ref> | |||
===Other ancillary studies=== | ===Other ancillary studies=== | ||