Difference between revisions of "Hypertension"
Jump to navigation
Jump to search
(→Heart) |
m (→References) |
||
| Line 50: | Line 50: | ||
==References== | ==References== | ||
{{reflist| | {{reflist|2}} | ||
==External links== | ==External links== | ||
*[http://missinglink.ucsf.edu/lm/introductionneuropathology/Response%20_to_Injury/Microvascular.html Microvascular disease (ucsf.edu)]. | *[http://missinglink.ucsf.edu/lm/introductionneuropathology/Response%20_to_Injury/Microvascular.html Microvascular disease (ucsf.edu)]. | ||
[[Category:Cardiovascular pathology]] | [[Category:Cardiovascular pathology]] | ||
Revision as of 01:52, 24 September 2010
Hypertension is very common and affects multiple organs. Clinically, it is usually classified as primary (idiopathic) and secondary.
Brain
Charcôt-Bouchard aneurysms
General
- AKA miliary aneurysms.
- Intracerebral hemorrhages.
Microscopic
Features:[1]
- Small aneurysms (~300 micrometers) with a fusiform shape.
- Vessel wall changes:
- Early:
- Proliferation of arteriolar smooth muscle
- Late:
- Apoptotic smooth muscle cell death and collagen deposition.
- Early:
Image: C-B aneurysm (ucsf.edu).
Eye
- Blindness.
Hypertensive heart disease
General
- Treated with antihypertensives.
Gross
Features:[2]
- Left ventricular hypertrophy (concentric).
Notes:
- In the autopsy context, significant valvular heart disease should be absent.
Microscopic
Features:[2]
- Arteriolosclerosis of intramural coronary arteries and arterioles.
- Fibrosis of media.
- Peirarteriolar fibrosis.
Kidney
General
- May result in renal failure.
Microscopic
Features:[3]
- Fibrinoid necrosis of afferent and interlobular arteries (due to endothelial cell damage).
See also
References
- ↑ Auer RN, Sutherland GR (December 2005). "Primary intracerebral hemorrhage: pathophysiology". Can J Neurol Sci 32 Suppl 2: S3–12. PMID 16450803.
- ↑ 2.0 2.1 Schwartzkopff B, Strauer BE (2000). "Coronary reserve and arteriolosclerosis in hypertensive heart disease". Z Kardiol 89 Suppl 9: IX/132–5. PMID 11151783.
- ↑ Ono H, Ono Y (November 1997). "Nephrosclerosis and hypertension". Med. Clin. North Am. 81 (6): 1273–88. PMID 9356598.