Difference between revisions of "Ovarian tumours"
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==Mucinous adenocarcinoma of the ovary== | ==Mucinous adenocarcinoma of the ovary== | ||
*[[AKA]] ''ovarian mucinous adenocarcinoma''. | *[[AKA]] ''ovarian mucinous adenocarcinoma''. | ||
*[[AKA]] ''ovarian mucinous carcinoma''. | |||
===General=== | ===General=== | ||
*Malignant. | *Malignant. | ||
Revision as of 01:40, 30 October 2012
The article examines ovarian tumours including ovarian cancer.
An introduction to the ovary is in the ovary article, which also deals benign cysts.
What was labeled "ovarian cancer" in the past may really arise from fallopian tube.[1] The label tubo-ovarian cancer has been advocated to address this change. These tumours are dealt with in this article.
Clinical
Gynecologists use a scoring system to help decide which patients need surgery and estimate their pre-op risk of malignancy.
Risk of malignancy index
- Abbreviated RMI.
- There are two versions.[2]
Elements & points (RIM 2):[2]
- Ultrasound features.
- Significant findings: multilocular cyst, solid component, bilateral lesions, ascites, suspected intra-abdominal metastases (one finding=1 point, two or more findings=4 points).
- Menopause/pre-menopause status (menopausal=4 points, pre-menopausal=1 point).
- CA-125 (blood test) in U/ml.
![{\displaystyle RMI\ score=ultrasound\ score\ x\ menopausal\ score\ x\ CA125\ level\ [U/ml].}](https://wikimedia.org/api/rest_v1/media/math/render/svg/56115a229a23b386a1e8d74074cf8736fe51e021)
Interpretation:
- RMI > 200 -- predicts malignancy.
Classification
The Latta rule of fives
Can be divided as follows:[3][4]
- Surface epithelial tumours (most common).
- Sex cord stromal tumours (SCSTs).
- Germ cell tumours (GCTs).
- Metastatic tumours.
- Rare stuff that doesn't fit in any of the above (e.g. leiomyoma, angiosarcoma, ovarian small cell carcinoma of the hypercalcemic type).
Surface epithelial tumours:
- Serous carcinoma..
- Endometrioid carcinoma.
- Mucinous carcinoma.
- Transitional cell tumours[5] (Brenner tumour).
- Clear cell carcinoma.
Sex cord stromal tumours:
- Granulosa cell tumour (adult type, juvenile type).
- Sertoli cell tumour.
- Leydig cell tumour.
- Fibroma.
- Thecoma.
- Dysgerminoma.
- Endodermal sinus tumour (yolk sac tumour).
- Embryonal carcinoma.
- Choriocarcinoma.
- Teratoma.
Common special tumours
Tumours associated with endometriosis:[6]
- Endometrioid.
- Clear cell carcinoma.
- Endocervical mucinous (AKA Seroumucinous type and Muellerian type).
Solid ovarian tumours
Simple version: basically anything sex cord stromal.
List:[7]
- Brenner tumour.
- SCSTs:
- Fibroma.
- Thecoma.
- Fibrothecoma.
- Leydig tumour.
- Sertoli cell tumour.
- Sertoli-Leydig tumour.
- Granulosa cell tumour.
- Granulosa-theca cell tumour.
A morphologic approach
Where is the tumour arising?
- Central location -- think GCTs and SCST.
- Surface of ovary -- think surface epithelial tumour.
- If no surface is apparent... possibly obliterated by tumour.
Spindle cell morphology?
- Consider sex cord stromal tumours.
Nests of cells?
- Consider Brenner tumour.
Gland-like structures?
- Endometrioid carcinoma.
- Granulosa cell tumour.
- Definition: cellular debris within gland lumen.[8]
- Characteristic of colorectal adenocarcinoma, may be absent in ovarian tumours -- limited value.[9]
Grading of ovarian cancer
- Silverberg grading system,[10] aka universal grading system.
- Based on pattern, cytologic atypia and mitotic rate.
- System somewhat similar to breast grading, which can be remembered as: TMN (tubular formation, mitotic rate, nuclear atypia).
Silverberg system
- Pattern:
- Glandular = 1.
- Papillary = 2.
- Solid = 3.
- Cytologic atypia:
- Slight = 1.
- Moderate = 2.
- Marked = 3.
- Mitoses (see note below):
- 0-9/(0.345 x10 mm^2) = 1.
- 10-24/(0.345 x10 mm^2) = 2.
- >=25/(0.345 x10 mm^2) = 3.
Composite score (pattern score + cytologic score + mitotic score):
- Grade I = 3-5.
- Grade II = 6-7.
- Grade III = 8-9.
Note 1:
- Most resident microscopes have an eyepiece diameter of 22 mm. Thus, the approximate field diameter is 0.55 mm (22 mm/40 X = 0.55 mm), at highest magnification, and the field area is 0.23758 mm^2 (pi*(0.55/2)^2=0.23758 mm^2).
- The number of HPFs should be adjusted if the area per field is different than 0.345 mm^2.
- If the field diameter is 0.55 mm and the sample area is 3.45 mm^2, this is equivalent to 14.52 HPFs (3.45 mm^2 / 0.23758 mm^2 = 14.52); thus, it would be appropriate to use 15 HPFs and the cut points above.
Note 2:
- A not-so-good alternative is to adjust the number of mitotic counts a keep the number of HPFs (10) constant.
- If the mitotic rate per area is held constant, and the cut points are 9, 10 and 24, the equivalent mitoses per area are:
- 0-4 mitoses/((HPF of 0.345 mm^2) x 10) = 1.
- 5-11 mitoses/((HPF of 0.345 mm^2) x 10) = 2.
- 12+ mitoses/((HPF of 0.345 mm^2) x 10) = 3.
- If the mitotic rate per area is held constant, and the cut points are 9, 10 and 24, the equivalent mitoses per area are:
Value of Silverberg...
Good correlation with five year survival (rounded values):[11]
- Grade I = 90%.
- Grade II = 65%.
- Grade III = 40%.
Peritoneal implants
General
- In the setting of serous borderline tumours there is much ado about implants.
Classification
There are two types:[12]
- Non-invasive implants.
- Subdivided into:
- Epithelial.
- Desmoplastic.
- Subdivided into:
- Invasive implants -- malignant cells within the stroma.
Notes:
- Invasive implants are significant clinically.
- Non-invasive implants have little clinical significance.
Microscopic
Non-invasive implant
Features (non-invasive implant epithelial-type):[13]
- Papillary proliferation on surface.
- +/-Smooth contoured invagination into:
- Submesothelium.
- Omental fat lobules.
- No "stromal response":
- Fibrosis.
- +/-Psammoma bodies.
Features (non-invasive implant desmoplastic-type):[13]
- Stromal reaction restricted to the:
- Serosal surface.
- Fibrous septae.
- +/-Psammoma bodies.
Note:
- No "destructive invasion".
- Irregular infiltration.
Invasive implant
Features (invasive implant):[13]
- Irregular infiltration of tumour into the submesothelial tissue - key feature - characterized by:
- +/-Solid nests.
- +/-Small glands +/- irregular "bridging" connections between glands - common.
- Nuclear atypia - common.
- +/-Psammoma bodies.
Stains
- Elastin stain:[12]
- Non-invasive implants are sit superficial to the peritoneal elastic lamina (PEL).
- Invasive implants are deep to the PEL.
Note:
- Elastin layer is not present in the omentum.
IHC
- Elastin stain.
Surface epithelial tumours
Most common subtypes - in short:[14]
- Serous:
- Columnar cells.
- Cilia.
- Psammoma bodies.
- Papillae.
- Endometrioid:
- Tubular glands.
- Squamous differentiation (eosinophilic cytoplasm, well-defined cell borders, +/-keratin).
- Mucinous:
- Tall columnar cells with mucin.
- Glands with mucin.
Where to start when considering a malignant (epithelial) tumour of the ovary:
| Features | Serous | Endometrioid | Mucinous |
|---|---|---|---|
| Histology | low grade: cilia, columnar cells, psammoma bodies, papillary arch.; high grade: marked nuclear pleomorphism, prominent red nucleoli, psammoma bodies | gland forming - esp. cribriforming, endometrium-like | mucinous glands, colon-like |
| Differentiators | cilia, psammoma bodies | squamous metaplasia | mucin, often lack of necrosis |
| Associations | atrophy | endometriosis, endometrial hyperplasia | (?) |
| Typical age | usually 60s+ | 40-60 | varies (?) |
| Grade | typically high grade | typically low grade | often low |
| IHC | p53 +ve (diffuse), WT-1 +ve, CA-125 +ve, D2-40 +ve | WT-1 -ve | CK7 +ve, CK20 +ve (other tumours CK7 +ve, CK20 -ve) |
| Main DDx | poorly diff. endometrioid | serous | metastatic tumour (usually GI) |
Serous tumours - overview
General
- Most common malignant ovarian tumour.
Classification
Based on features predictive of behaviour:[15]
- Benign.
- Borderline.
- May have pseudostratification of epithelial cells.
- "Usually, borderline if first impression is borderline."[16]
- Malignant.
- Cytologic atypia.
- +/-Papillae.
Microscopic
Features:[15]
- Tubal like epithelium:
- Ciliated.
- Columnar.
- Papillae.
- Psammoma bodies (concentric calcifications).
Note:
- In serous borderline tumours, micropapillae are thought to have significance -- assoc. with increased risk of distant recurrence[17][18][19] - though is disputed.[20]
- Psammoma bodies may be seen in endosalpingiosis.[21]
Serous carcinoma of the ovary
- AKA ovarian serous carcinoma.
General
- Most common malignant ovarian tumour in the eldery.
- Poor prognosis.
Microscopic
Features:
- Marked nuclear pleomorphism:
- Variation in size - usually marked.
- Variation in staining.
- Variation in shape.
- Prominent nucleolus - key feature.
- Eccentric nucleus.
- Architecture:
- Solid.
- Papillary - classic.
- Glandular - uncommon.
- +/-Psammoma bodies - uncommon.
- +/-Necrosis - often extensive.
DDx:
- Clear cell carcinoma of the ovary - less nuclear size variation.
- Endometrioid carcinoma of the ovary - usu. lower grade.
- Primary peritoneal serous carcinoma - bulk of tumour in peritoneum, small ovarian tumour.
- Other non-ovarian serous carcinomas - see serous carcinoma.
Images:
IHC
- CK7 +ve.
- WT-1 +ve.
- CA-125 +ve.
- ER +ve.[22]
- p53 +ve.
Others:
- HNF-1beta -ve.[23][24]
- Usually +ve in clear cell carcinoma of the ovary.
Serous cystadenoma of the ovary
- AKA ovarian serous cystadenoma.
General
- Benign.
- Very common.
- Not related to the serous cystadenoma of the pancreas.
Gross
- Usually unilocular.
Microscopic
Features:
- Simple epithelium with cilia - key feature.
- Cell morphology: columnar, cuboidal or flatted.
DDx:
- Serous cystadenofibroma.
Ovarian serous borderline tumour
- AKA serous borderline tumour of the ovary.
- AKA serous tumour of low malignant potential of the ovary, abbreviated SLMP.[25][26]
- AKA serous ovarian tumour of low malignant potential.[26]
General
- Usually benign.
- Require long term follow-up.
Microscopic
Features:
- Simple serous epithelium - with cilia.
- +/-Micropapillary architecture - often described as a medusa head pattern.
DDx:
- Serous carcinoma of the ovary.
- Clear cell carcinoma of the ovary - classically associated with endometriosis, have simpler, smaller papillae without branching.
Images:
Subclassification
Typical subdivided into:[27]
- Micropapillary serous borderline tumour.
- Typical serous borderline tumour (SBOT).
Seromucinous borderline tumor of the ovary
General
- Rare.
- Associated with endometriosis.
Gross
- Mucin-filled cysts.
Image:
Microscopic
Features:
- Simple mucinous epithelium - endocervical type.[29]
- Tall columnar epithelium with apical pale cytoplasm.
- Simple serous epithelium - with cilia.
Mucinous tumours - overview
General
- Common.
- Tumours may be heterogenous; benign appearing epithelium may be beside clearly malignant epithelium.
- Good sampling of mucinous tumours, i.e. many blocks, is important to lessen the chance of undercalling them.
Subtypes
- Endocervical type.
- Less likely to be malignant.
- More common than malignant type.
- Intestinal type.
- More likely to be malignant.
- Goblet cells. (???)
- One large clear apical vacuole.
- If it doesn't look like intestine to you... it probably isn't.
- May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).
- Image: [1]
![[1]](http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg){kind=link}
Comparison of mucosa:
- Normal endocervical mucosa: endocervical mucosa.
- Normal colonic mucosa: colonic type mucosa.
Classification
- Benign. (Dx: mucinous cystadenoma or mucinous adenofibroma or mucinous cystadenofibroma)
- Single layer of cells.
- Borderline. (Dx: mucinous tumour of uncertain malignant potential or borderline mucinous tumour)
- Papillae.
- Malignant. (Dx: mucinous adenocarcinoma)
- Usually intestinal subtype.
Mucinous adenocarcinoma of the ovary
General
- Malignant.
- May arise in endometriosis.[30]
- Poor response to chemotherapy vis-à-vis serous carcinoma.[31]
Gross
Features:
- Multiloculated.
- Sticky, gelatinous fluid (glycoprotein).
- +/-Necrosis.
Microscopic
Features:
- Tall columnar cells in glands.
- Apical mucin.
- May vaguely resemble colorectal adenocarcinoma.
- Glands have mucin.
- +/-Nuclear atypia.
- No cilia.
- +/-Necrosis.
Subtypes
- Endocervical type.
- Less likely to be malignant.
- More common than malignant type.
- Intestinal type.
- More likely to be malignant.
- Goblet cells. (???)
- One large clear apical vacuole.
- If it doesn't look like intestine to you... it probably isn't.
- May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).
- Image: [2]
Comparison of mucosa:
- Normal endocervical mucosa: endocervical mucosa.
- Normal colonic mucosa: colonic type mucosa.
IHC
- CK7 +ve.
- CK20 +ve.
Endometrioid carcinoma of the ovary
- AKA endometrioid ovarian carcinoma.
- AKA endometrioid adenocarcinoma of the ovary.
- AKA ovarian endometrioid adenocarcinoma.
General
- Associated with endometriosis, i.e. people with endometriosis are more likely to have 'em.
Gross
- Usually solid and cystic.
Image:
Microscopic
Features:
- Tubular glands.
- Cribriform pattern common.
- May see mucinous secretion.[32]
- May have squamous differentiation/squamous metaplasia (useful for differentiating from sex-cord stromal tumours and germ cell tumours).[32] - very useful feature.
DDx:
- Sertoli-Leydig cell tumour - also has tubules.
- Serous carcinoma of the ovary.
Clear cell carcinoma of the ovary
- AKA ovarian clear cell adenocarcinoma, abbreviated OCCC.
- AKA ovarian clear cell carcinoma.
- AKA clear cell adenocarcinoma of the ovary.
General
- Thought to be related to endometrioid carcinoma.[33]
- Worse prognosis versus other surface epithelial tumours.[34]
- Poor response to platinum-based chemotherapy.[35]
- Asians appear to be at an increased risk.[35]
Association with endometriosis:[35]
- Increased risk of ovarian clear cell carcinoma ~ 3x.
- Seen in 50-70% of ovarian CCC.
Gross
Features:[35]
- Usually unilateral (unlike serous carcinoma).
- Yellow colour.
Microscopic
Features:
- Cystic/tubular architecture - important low power feature.
- May be papillary and/or solid.
- Clear cells - cytoplasm is clear - key feature. †
- Hobnail morphology - apical surface larger than basal surface.
- "Nuclei bulge into the lumen".
- Hyaline droplets -- common, as in clear cell renal cell carcinoma.
- Eosinophilic bodies within lumen.
- Seen in approximately 1/4 of cases.[35]
- Nucleoli - prominent.
Note:
- † Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like papillary thyroid carcinoma -- which often isn't papillary -- see no truth in names.
- The hobnail morphology is important if this is the case.
DDx:
- Serous carcinoma of the ovary - have larger papillae +/- branching +/-multilayered epithelium, more mitotic activity,[35] more group pleomorphism.
- Serous borderline tumour of the ovary.
- High-grade endometrioid carcinoma of the ovary.
- Metatstatic clear cell carcinoma, esp. clear cell renal cell carcinoma.
- Borderline clear cell lesion of the ovary - very rare; an under sampled carcinoma considered more probable.[35]
- Arias-Stella reaction within endometriosis.
Images:
- WC:
- www:
IHC
Panel for high grade serous vs. clear cell:[37]
- ER (+ve in serous),[22] HNF-1beta (+ve in clear cell), WT-1 (+ve in serous).
Others:[35]
- CK7 +ve -- may be focal.
- CK20 -ve.
- CD10 -ve.
- Often +ve in clear cell renal cell carcinoma.
Transitional cell carcinoma of the ovary
General
- Rare.
- Fits into the transistional cell tumours category - in the surface epithelial group of ovarian tumours.[5]
Microscopic
Features:[38]
- Cystic spaces:
- Small - punched-out border - very common.
- Large.
- Papillae, usu. large, blunt.
- Occasionally small and filiform.
- +/-Bizarre giant cells (35%)
- +/-Gland-like tubules.
- +/-Squamous differentiation.
- +/-Psammoma bodies.
- Cells:
- Moderate basophilic cytoplasm and little intervening stroma.
- Marked nuclear pleomorphism.
- Mitoses - common.
Notes:
- Resembles urothelial carcinoma.[39]
- No Brenner tumour component (benign or malignant) should be present.[39]
Images:
IHC
Features:[39]
- Vimentin +ve,
- CA-125 +ve.
- WT1 +ve.
- CK20 -ve.
- Thrombomodulin -ve.
- Uroplakin III -ve.
Notes:
- 1-6 usu. opposite pattern in urothelial cell carcinoma.
Brenner tumour
General
- Fits into the transistional cell tumours category - in the surface epithelial group of ovarian tumours.
Epidemiology
- Mostly benign clinical course.
- Thought to arise from Walthard cell rest.
- Frequently an incidental finding, i.e. oophorectomy was done for another reason.
- May be malignant.
Gross
Features:[40]
- Classically solid, well-circumscribed, light yellow.
- May be cystic.
Note:
- Borderline tumours classically solid and cystic with papillary projections into the cystic component.[40]
Microscopic
Features:
- Nests of transitional epithelium with cells that have:[33]
- A "coffee bean nucleus".
- Elliptical shape (nucleus).
- Nuclear grooves.[41]
- Distinct nucleoli.
- Moderate-to-abundant gray/pale cytoplasm.
- A "coffee bean nucleus".
- Dense fibrous stroma around nests.
Notes:
- Main DDx of Coffee bean nucleus = granulosa cell tumour.
- Stromal component may be predominant.
DDx:
Images:
Germ cell tumours
Main article: Germ cell tumours
These tumour are relatively uncommon, though are the most common grouping for young women.
Overview
- Dysgerminoma (most common).
- Female version of seminoma.
- Yolk sac tumour (endodermal sinus tumour).
- Embryonal carcinoma.
- Choriocarcinoma.
- Teratoma.
- Mixed GCT - 60% of GCTs are mixed.
- Common combinations:
- Teratoma + embryonal carcinoma + endodermal sinus tumour (yolk sac tumour) (TEE).
- Seminoma + embryonal (SE).
- Embryonal + teratoma (TE).
- Common combinations:
Mnemonic: SEE CT, S=Seminoma, Embryonal carcinoma, Endodermal Sinus Tumour, Choriocarcinoma, Teratoma.
Teratoma
Main article: Teratoma
- May be benign or malignant.
- Skin component only called "dermoid".
Dysgerminoma
General
Epidemiology:
- Most common GCT in females.
- Prognosis usually good.
Microscopic
Features:
- Fried egg appearance (clear cytoplasm, central nucleus).
- Nuclear membrane has "corners", i.e. is "squared-off" - or "polygonal".
- +/- Lymphocytes - often prominent.
- +/- Granulomata.
Dysgerminoma vs lymphoma:
- Dysgerminoma has "squared-off" nuclei,[43] i.e. the nuclei look are polygonal-shaped.
Gonadoblastoma
Main article: Gonadoblastoma
Details dealt with in the main article.
Microscopic
- Immature germ cells resembling Sertoli cells or granulosa cells.
- Cells with moderate cytoplasm is a trabecular or tubular architecture.
- Primitive germ cells resemble those of a dysgerminoma.
- Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
- +/-Calcification (very common).
Metastatic ovarian tumours
Main article: Metastases
Generally
- Mostly Muellerian origin (uterus, fallopian tube) or pelvic peritoneum.
Extramuellerian metastatic tumours
DDx:
- Breast.
- Gastrointestinal (GI) tract.
- Pseudomyxoma peritonei, usu. appendiceal origin.
- Krukenberg tumour = signet ring cell cancer with mucin production of GI origin.
Microscopic
Features:
- Predominantly surface involvement and nodular at low power.
- Signet ring cells (suggestive of GI or breast primary).
- Lymphovascular invasion.
Mucinous carcinoma - GI tract metastasis vs. primary ovarian
Gross
Features favouring metastatic disease:[46]
- Bilaterality -- both ovaries involved.
- Small unilateral tumour size -- <10 cm = metastatic.
- >13 cm = primary ovarian.
IHC
Ovarian tumours:
- Dipeptidase 1 (DPEP1) +ve.[47]
- CK7 +ve.
Sex cord stromal tumours
General
- Most are unilateral.[48]
IHC
- Most are positive for alpha-inhibin.[48]
- Most are positive for calretinin -- considered more sensitive than alpha-inhibin.[49]
- Melan A +ve.
- CD99 +ve.
Memory device MAC = melan A, alpha-inhibin, calretinin.
Sex cord tumour with annular tubules
- Abbreviated SCTAT.
- NOT sex cord tumour with angulated tubules.
General
- Associated with Peutz-Jeghers syndrome.[50]
- Large tumours more likely sporadic.
- Small tumours more likely Peutz-Jeghers syndrome and incidental.
- Usually benign.
- Malignant cases reported.[51]
Microscopic
Features:
- Well-circumscribed nests of cells with nuclei at the periphery.
- Annular tubules (ring-shaped tubules) with dense hyaline material.
Notes:
- Annular = shape of a ring.[52]
- May focally have features of Sertoli cell tumour or granulosa cell tumour.[53]
DDx:
- Sertoli-Leydig tumour - has double palisading with overlap of the layers.
- Granulosa cell tumour - have Call-Exner bodies, which don't have a well-defined/solid content.
- Brenner tumour - coffee-bean nuclei.
Images:
- www:
- WC:
Juvenile granulosa cell tumour
General
- May secrete estrogen.
- May present with endometrial pathology, e.g. endometrial hyperplasia or endometrioid endometrial carcinoma.
- May present as precocious puberty.[54]
- Reported in males.[55]
Gross
- Classically solid.
Microscopic
Features:
- Microcystic spaces.
- Moderate-to-marked nuclear atypia.
- Cuboidal-to-polygonal cell in sheets or stands or cords.
- Basophilic cytoplasm.
Notes:
- Juvenile variant of GCT has more nuclear pleomorphism.
Images:
- WC:
IHC
- Inhibin positive.[56]
- Inhibin negative in Brenner tumour.
- Calretinin +ve.
Molecular
- Currently not used for the diagnosis.
Adult granulosa cell tumour
- AKA granulosa cell tumour.
- Should not be confused with granular cell tumour.
- Ideally, it should be called adult granulosa cell tumour to avoid confusion with juvenile granulosa cell tumour.
General
- May secrete estrogen.
- May present with endometrial pathology, e.g. endometrial hyperplasia or endometrioid endometrial carcinoma.
- Occasionally secrete antrogens lead to virilization.[59]
Note:
- Normal granulosa cells convert androgen from the theca cells to estrogen and/or progesterone.[60]
Gross
- Classically solid.
Microscopic
Features:
- Classic appearance includes gland-like structures filled with acidophilic material (Call-Exner bodies).
- Small cuboidal to polygonal cell in sheets or stands or cords.
- Nuclear grooves.
Note:
- There is a "10% rule" -- if less than 10% of a SCST is granulosa cells... it isn't granulosa cell tumour.
- Juvenile variant of GCT has more nuclear pleomorphism.
DDx:
- Urothelial cell carcinoma (UCC).
- UCC usually has extensive necrosis.
- Brenner tumour.
- Sertoli cell tumour.
IHC
- Inhibin positive.[56]
- Inhibin negative in Brenner tumour.
- Calretinin +ve.
Molecular
- Currently not used for diagnosis.
Fibroma-thecoma group
- Some say fibromas and thecomas are related,[63] while others believe they should be considered distinct entities.[64]
- A combination of a fibroma and a thecoma is known as a fibrothecoma.
Note:
- Some discourage the use of the term fibrothecoma and sugguest calling tumours in the fibrom-thecoma group fibroma unless there are lipid-laden cells and more than minimal alpha-inhibin positivity.[48]
Ovarian fibroma
General
- May be a part of:
- Meigs syndrome (mnemonic FAR: fibroma, ascites, right pleural effusion).
- Nevoid basal cell carcinoma syndrome (NBCCS), AKA Gorlin syndrome.[65]
- In NBCCS classically - calcified and bilateral.[66]
- Very rarely transform to fibrosarcoma <1%.[67]
Gross
Features:
- Solid white mass, usu. well-circumscribed.[68]
Note:
- Thecoma = yellow solid mass.[68]
Images:
Microscopic
- Spindle-shaped cells.
- Central nuclei.
- Stainable lipid - minimal or none.[48]
Images:
IHC
- Inhibin -ve (~75%).[48]
Thecoma
General
- Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.[64]
- Approx. 50% have symptoms related to estrogen secretion.[48]
- May also be viralizing.
Gross
Features:
- Solid yellow mass, usu. well-circumscribed.[68]
DDx:
- Ovarian fibroma - white solid mass.[68]
- Fibroma-thecoma (fibrothecoma).
Microscopic
Features:[48]
- Nuclei with oval to spindle morphology.
- Abundant cytoplasm that is pale, vaculolated -- key feature.
Images:
IHC
- Alpha-inhibin +ve (90%+).[48]
Sertoli-Leydig cell tumour
- AKA androblastoma.
General
- Sertoli and leydig cells are normal in the testis.
- Poorly differentiated tumours have sarcomatous features.[65]
Microscopic
Features:
- Sertoli or Leydig cells.[65]
- Leydig cells:
- Abundant solid eosinophilic cytoplasm.
- Round nuclei with fine chromatin and a small or indistinct nucleolus.
- Often in small clusters ~ 5-25 cells/cluster.
- Sertoli cells:
- Pale/clear vacuolated cytoplasm.
- Irregular nuclei with irregular/vacuolated-appearing chromatin.
- Architecture: tubules, cords or sheets.
- Leydig cells:
- Stroma.
- +/- Sarcomatous features (mucinous glands, bone, cartilage).
DDx:
Images:
- WC:
- www:
Hilus cell tumour
Main article: Leydig cell tumour
General
- Rare.[70]
- May cause virilization.
- Development of male (sexual) characteristics in a female.
- Arise from hilus cells.
Microscopic
Features - see Leydig cell tumour:
- Moderate eosinophilic cytoplasm.
- +/-Reinke crystalloids (cytoplasmic inclusions).
DDx:
- Hilus hyperplasia.
- Sertoli-Leydig tumour.
Benign
- Benign mesothelial inclusion cyst - may mimic a tumour.
See also
References
- ↑ Hirst, JE.; Gard, GB.; McIllroy, K.; Nevell, D.; Field, M. (Jul 2009). "High rates of occult fallopian tube cancer diagnosed at prophylactic bilateral salpingo-oophorectomy.". Int J Gynecol Cancer 19 (5): 826-9. doi:10.1111/IGC.0b013e3181a1b5dc. PMID 19574767.
- ↑ 2.0 2.1 URL: http://www.sign.ac.uk/guidelines/fulltext/75/section3.html. Accessed on: 16 September 2011.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1093. ISBN 0-7216-0187-1.
- ↑ LAE. 22 October 2009.
- ↑ 5.0 5.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 401. ISBN 978-0781765275.
- ↑ LAE. 22 October 2009.
- ↑ NEED REF.
- ↑ http://www.cancer.gov/cancertopics/genetics-terms-alphalist/all#D. Accessed on: 14 September 2011.
- ↑ DeCostanzo DC, Elias JM, Chumas JC (July 1997). "Necrosis in 84 ovarian carcinomas: a morphologic study of primary versus metastatic colonic carcinoma with a selective immunohistochemical analysis of cytokeratin subtypes and carcinoembryonic antigen". Int. J. Gynecol. Pathol. 16 (3): 245–9. PMID 9421090.
- ↑ Silverberg SG (January 2000). "Histopathologic grading of ovarian carcinoma: a review and proposal". Int. J. Gynecol. Pathol. 19 (1): 7-15. PMID 10638449. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0277-1691&volume=19&issue=1&spage=7.
- ↑ Sato Y, Shimamoto T, Amada S, Asada Y, Hayashi T (January 2003). "Prognostic value of histologic grading of ovarian carcinomas". Int. J. Gynecol. Pathol. 22 (1): 52-6. PMID 12496698. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0277-1691&volume=22&issue=1&spage=52.
- ↑ 12.0 12.1 Stewart, CJ.; Brennan, BA.; Crook, ML.; Russell, P. (Sep 2007). "Value of elastin staining in the assessment of peritoneal implants associated with ovarian serous borderline tumours.". Histopathology 51 (3): 313-21. doi:10.1111/j.1365-2559.2007.02789.x. PMID 17727474.
- ↑ 13.0 13.1 13.2 Bell, DA.; Weinstock, MA.; Scully, RE. (Nov 1988). "Peritoneal implants of ovarian serous borderline tumors. Histologic features and prognosis.". Cancer 62 (10): 2212-22. PMID 3179935.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1096-7. ISBN 0-7216-0187-1.
- ↑ 15.0 15.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1096. ISBN 0-7216-0187-1.
- ↑ LAE. 19 February 2009.
- ↑ LAE. 19 February 2009.
- ↑ URL: http://www.ncbi.nlm.nih.gov/pubmed/15897738. Accessed on: 7 April 2011.
- ↑ Piura B, Rabinovich A, Yanai-Inbar I (2000). "Micropapillary serous carcinoma of the ovary: case report and review of literature". Eur. J. Gynaecol. Oncol. 21 (4): 374–6. PMID 11055486.
- ↑ Prat J, De Nictolis M (September 2002). "Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion". Am. J. Surg. Pathol. 26 (9): 1111-28. PMID 12218568. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=26&issue=9&spage=1111.
- ↑ Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. PMID 1774734.
- ↑ 22.0 22.1 DeLair, D.; Oliva, E.; Köbel, M.; Macias, A.; Gilks, CB.; Soslow, RA. (Jan 2011). "Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases.". Am J Surg Pathol 35 (1): 36-44. doi:10.1097/PAS.0b013e3181ff400e. PMID 21164285.
- ↑ Tsuchiya, A.; Sakamoto, M.; Yasuda, J.; Chuma, M.; Ohta, T.; Ohki, M.; Yasugi, T.; Taketani, Y. et al. (Dec 2003). "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.". Am J Pathol 163 (6): 2503-12. PMID 14633622. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed.
- ↑ 24.0 24.1 Online 'Mendelian Inheritance in Man' (OMIM) 189907
- ↑ Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
- ↑ 26.0 26.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
- ↑ Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.
- ↑ Shappell, HW.; Riopel, MA.; Smith Sehdev, AE.; Ronnett, BM.; Kurman, RJ. (Dec 2002). "Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.". Am J Surg Pathol 26 (12): 1529-41. PMID 12459620.
- ↑ Shappell, HW.; Riopel, MA.; Smith Sehdev, AE.; Ronnett, BM.; Kurman, RJ. (Dec 2002). "Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.". Am J Surg Pathol 26 (12): 1529-41. PMID 12459620.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1097. ISBN 0-7216-0187-1.
- ↑ Shimada, M.; Kigawa, J.; Ohishi, Y.; Yasuda, M.; Suzuki, M.; Hiura, M.; Nishimura, R.; Tabata, T. et al. (Jun 2009). "Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.". Gynecol Oncol 113 (3): 331-4. doi:10.1016/j.ygyno.2009.02.010. PMID 19275957.
- ↑ 32.0 32.1 Baker P, Oliva E (July 2008). "A practical approach to intraoperative consultation in gynecological pathology". Int. J. Gynecol. Pathol. 27 (3): 353-65. doi:10.1097/PGP.0b013e31815c24fe. PMID 18580313.
- ↑ 33.0 33.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1098. ISBN 0-7216-0187-1.
Cite error: Invalid
<ref>tag; name "Ref_PBoD1098" defined multiple times with different content - ↑ Hauptmann S, Köbel M (2005). "[Prognostic factors in ovarian carcinoma]" (in German). Verh Dtsch Ges Pathol 89: 92-100. PMID 18035678.
- ↑ 35.0 35.1 35.2 35.3 35.4 35.5 35.6 35.7 Offman, SL.; Longacre, TA. (Sep 2012). "Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).". Adv Anat Pathol 19 (5): 296-312. doi:10.1097/PAP.0b013e31826663b1. PMID 22885379.
- ↑ Tsuchiya, A.; Sakamoto, M.; Yasuda, J.; Chuma, M.; Ohta, T.; Ohki, M.; Yasugi, T.; Taketani, Y. et al. (Dec 2003). "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.". Am J Pathol 163 (6): 2503-12. PMID 14633622. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed.
- ↑ Köbel M, Kalloger SE, Carrick J, et al. (January 2009). "A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary". Am. J. Surg. Pathol. 33 (1): 14–21. doi:10.1097/PAS.0b013e3181788546. PMID 18830127.
- ↑ Eichhorn, JH.; Young, RH. (Apr 2004). "Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis.". Am J Surg Pathol 28 (4): 453-63. PMID 15087664.
- ↑ 39.0 39.1 39.2 Tazi, EM.; Lalya, I.; Tazi, MF.; Ahellal, Y.; M'rabti, H.; Errihani, H. (2010). "Transitional cell carcinoma of the ovary: a rare case and review of literature.". World J Surg Oncol 8: 98. doi:10.1186/1477-7819-8-98. PMID 21073751.
- ↑ 40.0 40.1 Borah, T.; Mahanta, RK.; Bora, BD.; Saikia, S. (Jan 2011). "Brenner tumor of ovary: An incidental finding.". J Midlife Health 2 (1): 40-1. doi:10.4103/0976-7800.83273. PMC 3156501. PMID 21897739. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156501/.
- ↑ URL: http://www.pathologyoutlines.com/ovarytumor.html#brennergen. Accessed on: 8 February 2011.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1101. ISBN 0-7216-0187-1.
- ↑ Baker P, Oliva E (July 2008). "A practical approach to intraoperative consultation in gynecological pathology". Int. J. Gynecol. Pathol. 27 (3): 353?65. doi:10.1097/PGP.0b013e31815c24fe. PMID 18580313.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970245-5. Accessed on: 8 April 2011.
- ↑ Yemelyanova, AV.; Vang, R.; Judson, K.; Wu, LS.; Ronnett, BM. (Jan 2008). "Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification.". Am J Surg Pathol 32 (1): 128-38. doi:10.1097/PAS.0b013e3180690d2d. PMID 18162780.
- ↑ Okamoto, T.; Matsumura, N.; Mandai, M.; Oura, T.; Yamanishi, Y.; Horiuchi, A.; Hamanishi, J.; Baba, T. et al. (Feb 2011). "Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.". Mod Pathol 24 (2): 267-76. doi:10.1038/modpathol.2010.204. PMID 21076463.
- ↑ 48.0 48.1 48.2 48.3 48.4 48.5 48.6 48.7 48.8 Roth LM (July 2006). "Recent advances in the pathology and classification of ovarian sex cord-stromal tumors". Int. J. Gynecol. Pathol. 25 (3): 199–215. doi:10.1097/01.pgp.0000192271.22289.e6. PMID 16810055.
- ↑ Movahedi-Lankarani, S.; Kurman, RJ. (Nov 2002). "Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases.". Am J Surg Pathol 26 (11): 1477-83. PMID 12409724.
- ↑ Purohit, RC.; Alam, SZ. (Mar 1980). "Sex cord tumour of the ovary with annular tubules (SCTAT).". Histopathology 4 (2): 147-54. PMID 7358344.
- ↑ Lele, SM.; Sawh, RN.; Zaharopoulos, P.; Adesokan, A.; Smith, M.; Linhart, JM.; Arrastia, CD.; Krigman, HR. (Apr 2000). "Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report.". Mod Pathol 13 (4): 466-70. doi:10.1038/modpathol.3880079. PMID 10786816.
- ↑ URL: http://dictionary.reference.com/browse/annular. Accessed on: 6 August 2011.
- ↑ Young, RH.; Welch, WR.; Dickersin, GR.; Scully, RE. (Oct 1982). "Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and four with adenoma malignum of the cervix.". Cancer 50 (7): 1384-402. PMID 7104978.
- ↑ Hashemipour, M.; Moaddab, MH.; Nazem, M.; Mahzouni, P.; Salek, M. (Jul 2010). "Granulosa cell tumor in a six-year-old girl presented as precocious puberty.". J Res Med Sci 15 (4): 240-2. PMID 21526089.
- ↑ URL: http://path.upmc.edu/cases/case631.html. Accessed on: 26 January 2012.
- ↑ 56.0 56.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1102. ISBN 0-7216-0187-1.
- ↑ Schofield, DE.; Fletcher, JA. (Dec 1992). "Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.". Am J Pathol 141 (6): 1265-9. PMID 1466394.
- ↑ Mayr, D.; Kaltz-Wittmer, C.; Arbogast, S.; Amann, G.; Aust, DE.; Diebold, J. (Sep 2002). "Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors.". Mod Pathol 15 (9): 951-7. doi:10.1097/01.MP.0000024290.55261.14. PMID 12218213.
- ↑ Patel, SS.; Carrick, KS.; Carr, BR. (Mar 2009). "Virilization persists in a woman with an androgen-secreting granulosa cell tumor.". Fertil Steril 91 (3): 933.e13-5. doi:10.1016/j.fertnstert.2008.10.038. PMID 19062005.
- ↑ Havelock, JC.; Rainey, WE.; Carr, BR. (Dec 2004). "Ovarian granulosa cell lines.". Mol Cell Endocrinol 228 (1-2): 67-78. doi:10.1016/j.mce.2004.04.018. PMID 15541573.
- ↑ Jamieson, S.; Fuller, PJ. (Feb 2012). "Molecular pathogenesis of granulosa cell tumors of the ovary.". Endocr Rev 33 (1): 109-44. doi:10.1210/er.2011-0014. PMID 22240241.
- ↑ Shah, SP.; Köbel, M.; Senz, J.; Morin, RD.; Clarke, BA.; Wiegand, KC.; Leung, G.; Zayed, A. et al. (Jun 2009). "Mutation of FOXL2 in granulosa-cell tumors of the ovary.". N Engl J Med 360 (26): 2719-29. doi:10.1056/NEJMoa0902542. PMID 19516027.
- ↑ http://www.pathologyoutlines.com/ovarytumor.html#fibroma
- ↑ 64.0 64.1 Nocito AL, Sarancone S, Bacchi C, Tellez T (February 2008). "Ovarian thecoma: clinicopathological analysis of 50 cases". Ann Diagn Pathol 12 (1): 12–6. doi:10.1016/j.anndiagpath.2007.01.011. PMID 18164409.
- ↑ 65.0 65.1 65.2 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1103. ISBN 0-7216-0187-1.
Cite error: Invalid
<ref>tag; name "Ref_PBoD1103" defined multiple times with different content Cite error: Invalid<ref>tag; name "Ref_PBoD1103" defined multiple times with different content - ↑ Tytle, T.; Rosin, D. (Sep 1984). "Bilateral calcified ovarian fibromas.". South Med J 77 (9): 1178-80. PMID 6385289.
- ↑ URL: http://brighamrad.harvard.edu/Cases/bwh/hcache/353/full.html. Accessed on: 4 October 2011.
- ↑ 68.0 68.1 68.2 68.3 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.
- ↑ URL: http://www.pathologyoutlines.com/ovarytumor.html#fibroma. Accessed on: 7 May 2012.
- ↑ 70.0 70.1 Zafrakas, M.; Venizelos, ID.; Theodoridis, TD.; Zepiridis, L.; Agorastos, T.; Bontis, JN. (2009). "Virilizing ovarian hilus (Leydig) cell tumor with concurrent contralateral hilus cell hyperplasia: a rare diagnosis.". Eur J Gynaecol Oncol 30 (3): 338-40. PMID 19697637.