Difference between revisions of "Signet ring cell carcinoma"

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**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.
**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.


Images:
===Images===
*www:
www:
**[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)].  
*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)].  
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Signet_ring_cell_carcinoma_-_low_mag.jpg SRCC - low mag. - demonstrating that it can be subtle (WC/Nephron)].
Image:Signet_ring_cell_carcinoma_-_low_mag.jpg | SRCC - low mag. - demonstrating that it can be subtle. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Signet_ring_cell_carcinoma_-_high_mag.jpg SRCC - high mag. (WC/Nephron)].
Image:Signet_ring_cell_carcinoma_-_high_mag.jpg | SRCC - high mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCC metastasis (WC/Nephron)].
Image:Signet_ring_cells_5.jpg | SRCC metastasis. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC (WC/KGH)].
Image:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg | SRCC. (WC/KGH)
**[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRCC - PAS stain (WC/KGH)].
Image:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg | SRCC - PAS stain. (WC/KGH)
 
</gallery>
==Stains==
==Stains==
*PAS stain +ve.
*PAS stain +ve.

Revision as of 05:10, 20 May 2013

Signet ring cell carcinoma, abbreviated SRCC, is a type of malignant epithelial neoplasm that typically arises from the stomach.

General

  • It has been said that there are two types of pathologists... those that have missed SRCCs and those that will miss SRCCs.

Differential diagnosis

It may arise from the:[1]

Microscopic

Features:

  • Signet ring cells resemble signet rings.
    • They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
    • The pool of mucin in a signet ring cell mimics the appearance of the finger hole.
    • The nucleus mimics the appearance of the face of the ring in profile.
  • Signet ring cells are typically 2-3x the size of a lymphocyte.
    • Smaller than the typical adipocyte.
  • Often have a crescent-shaped or ovoid nucleus.
    • Capillaries sectioned on their lumen have endothelial cells - the nuclei of these are more spindled.

Note:

  • SRCs are usually close to friend, i.e. they are adjacent to another SRC.
    • This helps differentiate SRCs from capillaries sectioned on their lumen.
  • The mucin is often clear on H&E... but maybe eosinophilic.

DDx:

  • Serous fat atrophy.[2]
  • Mucocele - muciphages may mimic signet ring cells.[3]
    • Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.

Images

www:

  • SRCC - low mag. - demonstrating that it can be subtle. (WC/Nephron)

  • SRCC - high mag. (WC/Nephron)

  • SRCC metastasis. (WC/Nephron)

  • SRCC. (WC/KGH)

  • SRCC - PAS stain. (WC/KGH)

Stains

  • PAS stain +ve.
  • Alican blue-PAS stain +ve.

IHC

  • AE1/AE3 +ve.
  • CK7 +ve.

See also

References

  1. ↑ URL: http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer. Accessed on: 7 March 2012.
  2. ↑ Clarke, BE.; Brown, DJ.; Xipell, JM. (Jan 1983). "Gelatinous transformation of the bone marrow.". Pathology 15 (1): 85-8. PMID 6222282.
  3. ↑ De Petris, G.; Lev, R.; Siew, S. (May 1998). "Peritumoral and nodal muciphages.". Am J Surg Pathol 22 (5): 545-9. PMID 9591723.
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